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Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
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Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

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Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
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Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
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Related Experiment Video

Updated: Jun 18, 2025

An Experimental Model of Myocardial Infarction for Studying Cardiac Repair and Remodeling in Knockout Mice
09:29

An Experimental Model of Myocardial Infarction for Studying Cardiac Repair and Remodeling in Knockout Mice

Published on: July 14, 2023

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Understanding Galectin-3's Role in Diastolic Dysfunction: A Contemporary Perspective.

Wen-Rui Hao1,2, Chun-Han Cheng3, Ju-Chi Liu1,2

  • 1Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Ministry of Health and Welfare, Taipei Medical University, New Taipei City 23561, Taiwan.

Life (Basel, Switzerland)
|July 27, 2024
PubMed
Summary

Galectin-3 contributes to diastolic dysfunction, a key factor in heart failure with preserved ejection fraction (HFpEF). Understanding galectin-3

Keywords:
biomarkercardiac remodelingdiastolic dysfunctionfibrosisgalectin-3heart failure

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Area of Science:

  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Diastolic dysfunction impairs left ventricular filling, contributing to heart failure with preserved ejection fraction (HFpEF).
  • Galectin-3, a lectin, is implicated in cardiovascular fibrosis and inflammation.

Purpose of the Study:

  • To review the impact of galectin-3 on diastolic dysfunction.
  • To explore galectin-3's molecular mechanisms, diagnostic potential, and therapeutic implications in HFpEF.

Main Methods:

  • Comprehensive literature review of animal models and clinical studies.
  • Analysis of galectin-3's role in cellular signaling and extracellular matrix interactions.
  • Examination of galectin-3's involvement in cardiac remodeling, inflammation, and fibrosis.

Main Results:

  • Galectin-3 plays a significant role in the pathophysiology of diastolic dysfunction.
  • Evidence supports galectin-3's involvement in cardiac fibrosis and inflammation.
  • Galectin-3 shows potential as a biomarker and therapeutic target for HFpEF.

Conclusions:

  • Galectin-3 is a key mediator in diastolic dysfunction and HFpEF.
  • Further research into galectin-3 could improve diagnostic and therapeutic strategies.
  • Targeting galectin-3 may offer new treatment avenues for HFpEF patients.