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Published on: June 14, 2016
A Novel Characteristic Gastric Mucus Named "Web-like Mucus" Potentially Induced by Vonoprazan
Hiroaki Kaneko1, Hiroki Sato1, Yuichi Suzuki1
1Department of Gastroenterology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura Kanazawa-Ku, Yokohama 236-0004, Japan.
Abstract:
Background: In the absence of Helicobacter pylori (HP) infection, a characteristic gastric mucus adhesion may appear during the use of vonoprazan. We named this novel characteristic mucus "web-like mucus" (WLM). This study aimed to determine the incidence and risk factors for WLM. Methods: Between January 2017 and January 2022, 5665 patients were enrolled in this study. The patients were divided into a proton-pump inhibitor (PPI)-prescribed group (n = 2000), a vonoprazan-prescribed group (n = 268), and a no-PPI/vonoprazan-prescribed (n = 3397) group, and the presence of WLM was examined. After excluding four patients with autoimmune gastritis, the remaining 264 patients in the vonoprazan group were divided into WLM and non-WLM groups, and their clinical features were analyzed. Results: A total of 55 (21%) patients had WLM, all in the vonoprazan-prescribed group. There were no significant differences in factors such as, sex, age, chronic kidney disease, diabetes mellitus, HP eradication history, smoking, or alcohol consumption between the WLM and non-WLM groups. The median duration from the start of vonoprazan administration to the endoscopic detection of WLM was 2 (1-24) months. Conclusions: WLM appears to be a characteristic feature in patients treated with vonoprazan.
Insights
Web-like mucus (WLM) is a novel gastric adhesion observed in patients using vonoprazan without Helicobacter pylori infection. This study identified its incidence and found no significant risk factors among treated patients.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- A novel gastric mucus adhesion, termed web-like mucus (WLM), has been observed in patients using vonoprazan.
- This phenomenon occurs in the absence of Helicobacter pylori infection.
Purpose of the Study:
- To determine the incidence of WLM in patients treated with vonoprazan.
- To identify potential risk factors associated with WLM development.
Main Methods:
- A retrospective study of 5665 patients from January 2017 to January 2022.
- Patients were categorized into vonoprazan, proton-pump inhibitor (PPI), and no-acid-suppressant groups.
- Endoscopic examination was used to detect WLM, with subsequent analysis of clinical features in the vonoprazan group.
Main Results:
- Web-like mucus (WLM) was detected in 55 (21%) patients, exclusively within the vonoprazan-prescribed group.
- No significant differences in risk factors (sex, age, comorbidities, lifestyle) were found between WLM and non-WLM groups.
- The median time to WLM detection after starting vonoprazan was 2 months.
Conclusions:
- Web-like mucus (WLM) is a characteristic endoscopic finding in patients treated with vonoprazan.
- The development of WLM appears independent of common clinical and lifestyle factors.
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