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Early Outcomes of Two Large Mitral Valve Transcatheter Edge-to-Edge Repair Devices-A Propensity Score Matched
Philipp von Stein1, Hendrik Wienemann1, Jennifer von Stein1
1Department of Cardiology, Heart Center, Faculty of Medicine, University of Cologne, 50937 Cologne, Germany.
Journal of Clinical Medicine
|July 27, 2024
Summary
The PASCAL and MitraClip XT(R/W) devices show comparable technical success and significant mitral regurgitation reduction after transcatheter edge-to-edge repair. PASCAL demonstrated an advantage in achieving severe mitral regurgitation reduction in functional MR patients.
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Devices
Background:
- Previous studies showed comparable outcomes between PASCAL and earlier MitraClip generations.
- Limited comparative data exist for contemporary MitraClip generations, especially the large MitraClip XT(R/W).
Purpose of the Study:
- To evaluate acute and 30-day outcomes of transcatheter edge-to-edge repair (M-TEER) using PASCAL P10 versus MitraClip XT(R/W) (3rd/4th generation).
Main Methods:
- Propensity score matching created 200 balanced pairs from 309 PASCAL and 253 MitraClip patients.
- Collected procedural, clinical, and echocardiographic outcomes up to 30 days.
- Subgroup analysis was performed for mitral regurgitation (MR) etiologies.
Main Results:
- Both devices achieved high technical success rates (PASCAL: 96.5%, MitraClip: 96.0%).
- Reduction to MR ≤2+ was comparable (PASCAL: 92.4%, MitraClip: 87.8%).
- PASCAL showed a higher rate of reduction to MR ≤1+ (67.7% vs. 56.6%), particularly in functional MR (FMR) patients (74.0% vs. 60.0%).
Conclusions:
- Both M-TEER devices demonstrate high technical success and comparable MR reduction to ≤2+.
- PASCAL may offer an advantage in achieving MR reduction to ≤1+ for patients with FMR.
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