Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ingestible Smart Capsules for Chemical Sensing in the Gut.

Analytical chemistry·2025
Same author

Smart capsules for sensing and sampling the gut: status, challenges and prospects.

Gut·2023
Same author

Anchoring Mechanism for Capsule Endoscope: Mechanical Design, Fabrication and Experimental Evaluation.

Micromachines·2022
Same author

Inside the ensemble: unlocking the potential of one-at-a-time experiments with lab-on-a-chip automation.

Lab on a chip·2021
Same author

Optical Micromachines for Biological Studies.

Micromachines·2020
Same author

Micromanipulation System for Isolating a Single <i>Cryptosporidium</i> Oocyst.

Micromachines·2019

Related Experiment Video

Updated: Jun 18, 2025

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays
09:58

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays

Published on: June 23, 2022

2.1K

An Alternative Micro-Milling Fabrication Process for Rapid and Low-Cost Microfluidics.

Martin Christopher Allen1, Simon Lookmire1, Ebubekir Avci2

  • 1College of Sciences, School of Food and Advanced Technology, Massey University, Palmerston North 4410, New Zealand.

Micromachines
|July 27, 2024
PubMed
Summary

This study presents a rapid microfluidic chip fabrication method using micro-milling and ethanol bonding, producing high-quality channels. Surface roughness was found to impact microparticle control in these devices.

Keywords:
CNCimage processingmicro-CNC millingmicrofabricationmicrofluidicsmicroparticle manipulationprofilometry

More Related Videos

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications
05:33

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Published on: November 20, 2019

8.7K
High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
07:51

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

7.4K

Related Experiment Videos

Last Updated: Jun 18, 2025

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays
09:58

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays

Published on: June 23, 2022

2.1K
Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications
05:33

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Published on: November 20, 2019

8.7K
High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
07:51

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

7.4K

Area of Science:

  • Biomedical engineering
  • Materials science
  • Nanotechnology

Background:

  • Microfluidics is crucial for biomedical applications.
  • Advances in micro-milling enable cost-effective fabrication of complex microstructures.
  • Existing fabrication methods have limitations in speed and complexity.

Purpose of the Study:

  • To develop a rapid and cost-effective microfluidic chip fabrication process.
  • To investigate the impact of surface roughness on microparticle control.
  • To produce high-quality microfluidic devices for scientific research.

Main Methods:

  • Utilized a step-by-step microfluidic chip fabrication process with a self-contained wet milling chamber.
  • Employed ethanol solvent bonding for rapid assembly (approx. 1 hour).
  • Analyzed microchannel surface roughness using quantitative contact profileometry and assessed particle velocity via image processing.

Main Results:

  • Achieved high-quality microchannels comparable to existing studies.
  • Demonstrated that surface roughness significantly affects microparticle control within the channels.
  • Validated the rapid fabrication process for producing functional microfluidic devices.

Conclusions:

  • The developed micro-milling and ethanol bonding technique offers a rapid and high-quality method for microfluidic device fabrication.
  • Understanding surface roughness effects is key to optimizing microfluidic systems for particle manipulation.
  • This advancement can accelerate research and development in diverse scientific fields utilizing microfluidics.