Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K
Gene-Environment Interactions01:20

Gene-Environment Interactions

276
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
276
Anatomy of the Intestines01:23

Anatomy of the Intestines

71.7K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.7K
Proteomics01:33

Proteomics

7.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.3K
Genomics02:02

Genomics

36.2K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.2K
Surface Membrane Barriers01:18

Surface Membrane Barriers

1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ironing Out Possible Micronutrient Deficiencies Associated with Incretin Receptor Agonist-Based Therapies: Proposed Practical Strategies to Prevent and Manage Iron Deficiency.

Nutrients·2026
Same author

Exploring the Association Between Gut Microbiota and Infertility in Women with Multiple Implantation Failures: An Exploratory Study.

Microorganisms·2026
Same author

Serum Uric Acid as a Cardiovascular Risk Marker: Differential Effects of Ketogenic Diet and Intermittent Fasting in Postmenopausal Women.

Nutrients·2026
Same author

Tricuspid Regurgitation: Pathophysiology, Risk Stratification, and Implications for Intervention.

Journal of clinical medicine·2026
Same author

A Clinician-Oriented Approach to Plaque Pathology in ACS: Implications for Personalized Cardiovascular Medicine-A Comprehensive Review.

Journal of personalized medicine·2026
Same author

Multimodal Cardiac Imaging in Systemic Lupus Erythematosus: From Clinical Suspicion to Diagnosis in Clinical Practice.

Diagnostics (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jun 18, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

27.9K

The Relationship between Exposome and Microbiome.

Giuseppe Merra1, Paola Gualtieri1, Giada La Placa2

  • 1Department of Biomedicine and Prevention, Section of Clinical Nutrition and Nutrigenomics, University of Rome Tor Vergata, 00133 Rome, Italy.

Microorganisms
|July 27, 2024
PubMed
Summary

The exposome, encompassing all environmental exposures, and the human microbiome are interconnected. Understanding this relationship is crucial for a holistic view of health and disease, moving beyond traditional specificity-based medicine.

Keywords:
commensalsenvironmentalexposomemicrobiomeomicsorganisms

More Related Videos

Microbial Communities in Nature and Laboratory - Interview
29:13

Microbial Communities in Nature and Laboratory - Interview

Published on: May 28, 2007

6.2K
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
09:49

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

2.0K

Related Experiment Videos

Last Updated: Jun 18, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

27.9K
Microbial Communities in Nature and Laboratory - Interview
29:13

Microbial Communities in Nature and Laboratory - Interview

Published on: May 28, 2007

6.2K
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
09:49

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

2.0K

Area of Science:

  • Environmental Health Sciences
  • Microbiome Research
  • Systems Biology

Background:

  • Exposome studies utilize diverse monitoring tools, including sensors and omics analyses.
  • The exposome framework conceptualizes environmental influences on health from conception to death.
  • The human microbiome comprises microorganisms residing on host surfaces, offering protection against environmental exposures.

Purpose of the Study:

  • To explore the relationship between the exposome and the human microbiome.
  • To address knowledge gaps regarding the role of microorganisms within the exposome.
  • To shift from a specificity-based medical approach to a complexity-based understanding of health.

Main Methods:

  • Review and synthesis of current exposome and microbiome research.
  • Conceptual analysis of the interplay between environmental factors and microbial communities.
  • Integration of exposome concepts with microbiome science.

Main Results:

  • The exposome and microbiome share structural and functional similarities.
  • Microorganisms within the human microbiome exhibit resistance to environmental exposures.
  • A comprehensive understanding of health requires integrating exposome and microbiome data.

Conclusions:

  • The interaction between the exposome and microbiome is critical for maintaining health-disease equilibrium.
  • Further research is needed to fully elucidate the role of microorganisms in the exposome.
  • This integrated approach supports a complexity-based paradigm in health and precision public health.