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Updated: Jun 18, 2025
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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
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Multiple Functions of Hepatitis E Virus ORF3.
Fengyuan Jiao1, Yu Zhao2, Gengxu Zhou1
1The College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
Microorganisms
|July 27, 2024
Summary
Hepatitis E virus (HEV) ORF3 protein influences host cell pathways, impacting viral spread and immune evasion. This review explores ORF3
Area of Science:
- Virology
- Molecular Biology
- Immunology
Background:
- Hepatitis E (HE) is a global public health concern, primarily caused by Hepatitis E virus (HEV).
- HEV possesses three Open Reading Frames (ORFs): ORF1, ORF2, and ORF3, each with distinct functions.
- Research on HEV pathogenesis has predominantly focused on ORF1 and ORF2, with limited investigation into ORF3.
Purpose of the Study:
- To review the multifaceted roles of HEV ORF3 protein in viral pathogenesis.
- To explore ORF3's impact on host cellular pathways, including the ERK pathway and growth factors.
- To summarize ORF3's influence on immune responses and viral release mechanisms.
Main Methods:
- Comprehensive literature review of studies investigating Hepatitis E virus ORF3.
- Analysis of research focusing on ORF3's interactions with host cell signaling pathways.
- Synthesis of findings related to ORF3's role in immune modulation and virus egress.
Main Results:
- HEV ORF3 protein modulates the Extracellular signal-Regulated Kinase (ERK) pathway.
- ORF3 influences the expression and activity of host growth factors.
- The ORF3 protein plays a role in modulating the host immune response and facilitating virus release.
Conclusions:
- HEV ORF3 is a critical viral factor influencing host cell biology and viral propagation.
- Understanding ORF3's functions provides insights into HEV pathogenesis.
- Targeting ORF3 may offer novel strategies for Hepatitis E prevention and treatment.
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