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Related Concept Videos

Anxiolytic Drugs: Overview01:26

Anxiolytic Drugs: Overview

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Anxiolytic drugs are vital in managing anxiety disorders by effectively alleviating symptoms such as excessive fear, tachycardia, and tremors. There are several classes of anxiolytic medications, each with unique mechanisms of action and potential side effects.
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
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Updated: Jun 18, 2025

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Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria.

Cristina N Coffman1,2, Amanda Carroll-Portillo2,3, Joe Alcock4

  • 1Biomedical Research Institute of New Mexico, Albuquerque, NM 87108, USA.

Microorganisms
|July 27, 2024
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Psychological stress can cause gut bacteria blooms, increasing anxiety. Magnesium oxide (MgO) inhibited these bacteria and reduced stress-induced anxiety-like behaviors in mice, suggesting a reversible link.

Keywords:
DeferribacterotaDesulfovibriodysbiosishydrogen sulfide (H2S)sulfate-reducing bacteria (SRB)

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Area of Science:

  • Neuroscience
  • Microbiology
  • Gastroenterology

Background:

  • The gut microbiota-brain axis facilitates communication between the gut microbiome and the central nervous system.
  • Psychological stress can induce gut dysbiosis, potentially leading to anxiety-like behaviors.
  • The role of commensal bacteria in the gut-brain axis and anxiety remains unclear.

Purpose of the Study:

  • To investigate the impact of commensal sulfate-reducing bacteria (SRB) and their metabolite hydrogen sulfide (H₂S) on anxiety-like behavior.
  • To evaluate the efficacy of magnesium oxide (MgO) in modulating SRB growth and H₂S production.
  • To explore the potential of MgO in mitigating stress-induced SRB blooms and associated anxiety.

Main Methods:

  • Mice were gavaged with SRB to assess anxiety-like behavior using the open field test.
  • In vitro and in vivo experiments using a water avoidance stress (WAS) model were conducted to test MgO's effects on SRB.
  • MgO's impact on SRB overgrowth and anxiety-like behavior in stressed mice was evaluated.

Main Results:

  • Gavage with SRB increased anxiety-like behavior in mice.
  • MgO inhibited SRB growth and H₂S production in a dose-dependent manner.
  • WAS induced SRB blooms (Deferribacterota) and anxiety-like behavior, which were attenuated by a MgO-enriched diet.

Conclusions:

  • Commensal SRB and their metabolite H₂S may contribute to anxiety-like behavior.
  • MgO effectively inhibits SRB growth and H₂S production.
  • MgO may offer a therapeutic strategy to reverse stress-induced SRB blooms and anxiety-like behaviors via the gut-brain axis.