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Related Concept Videos

Pharmacovigilance01:19

Pharmacovigilance

805
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
805
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

209
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
209
Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

413
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
413
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

343
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
343
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

236
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
236
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

110
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
110

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Related Experiment Video

Updated: Jun 18, 2025

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
07:58

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression

Published on: February 24, 2023

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Sexual Dysfunction Induced by Antidepressants-A Pharmacovigilance Study Using Data from VigiBaseTM.

Rene Zeiss1, Kathrin Malejko1, Bernhard Connemann1

  • 1Department of Psychiatry and Psychotherapy III, University of Ulm, Leimgrubenweg 12-14, 89075 Ulm, Germany.

Pharmaceuticals (Basel, Switzerland)
|July 27, 2024
PubMed
Summary

Antidepressants, especially SSRIs and SNRIs, are frequently linked to sexual dysfunction. Understanding these side effects and their pharmacodynamic links is crucial for effective patient care and treatment adherence.

Keywords:
adverse drug reactionantidepressant-induced sexual dysfunctiondisproportionality analysispharmacovigilance

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Area of Science:

  • Pharmacovigilance
  • Neuroscience
  • Clinical Pharmacology

Background:

  • Sexual dysfunction is a prevalent and often distressing side effect of antidepressant medications.
  • This significantly impacts patient quality of life and adherence to treatment regimens.
  • Understanding the specific drug-associated risks is essential for clinical practice.

Purpose of the Study:

  • To investigate the association between various antidepressants and sexual dysfunction.
  • To explore the pharmacodynamic underpinnings of antidepressant-induced sexual side effects.
  • To provide data supporting informed clinical decision-making regarding antidepressant selection.

Main Methods:

  • Analysis of individual case safety reports from VigiBase™.
  • Calculation of reporting odds ratios (RORs) for sexual dysfunction adverse events.
  • Correlation analysis between RORs and antidepressant binding affinities to neurotransmitter targets.

Main Results:

  • High disproportional reporting of sexual dysfunction identified for selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs).
  • Lower reported associations for agomelatine, bupropion, and mirtazapine.
  • Significant positive correlation found between serotonin transporter binding affinity and sexual desire side effects (r = 0.67, p = 0.001).

Conclusions:

  • Clinicians must proactively consider and manage sexual side effects when prescribing antidepressants.
  • Pharmacodynamic properties, particularly serotonin transporter interaction, are implicated in sexual dysfunction.
  • Improved patient outcomes depend on monitoring and addressing these adverse effects.