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VIGS-Mediated Forward Genetics Screening for Identification of Genes Involved in Nonhost Resistance

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Engineered Resistance to Tobamoviruses.

John Peter Carr¹

¹Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK.

|July 27, 2024

Summary

This summary is machine-generated.

Tobamoviruses, including Tobacco Mosaic Virus (TMV), are re-emerging crop threats. This review explores molecular strategies like gene editing and RNA silencing for tobamovirus crop protection.

Keywords:

NB-LRR protein RNAi artificial microRNA crop protection mosaic virus nanoparticle RNA delivery novel viruses pathogen-derived resistance plant disease plant gene editing

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Engineering Antiviral Agents via Surface Plasmon Resonance

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Published on: June 14, 2022

Area of Science:

Plant pathology
Molecular virology
Biotechnology

Background:

Tobacco Mosaic Virus (TMV) and related tobamoviruses have historically impacted tomato and pepper crops.
While resistance genes offered control, new strains like Tomato Brown Rugose Fruit Virus (TBRFV) and spreading Cucumber Green Mottle Mosaic Virus (CGMMV) pose current threats.
Tobamoviruses remain vital models in molecular biology, biotechnology, and nanobiotechnology.

Purpose of the Study:

To review molecular biology-based strategies for protecting crops against tobamoviruses.
To highlight recent challenges posed by emerging and spreading tobamovirus strains.
To discuss advancements in crop protection against viral pathogens.

Main Methods:

Cross-protection using mild tobamovirus strains.
Transgenic expression of viral gene products to inhibit infection.
RNA silencing induced by virus-derived RNA sequences or double-stranded RNA application.
Gene editing of host susceptibility factors.
Transfer and optimization of natural resistance genes.

Main Results:

Various molecular approaches demonstrate potential for tobamovirus control.
Emerging tobamoviruses overcome existing resistance, necessitating new strategies.
RNA silencing and gene editing show promise for broad-spectrum resistance.
Integration of natural resistance genes offers durable crop protection.

Conclusions:

Molecular strategies offer diverse avenues for managing tobamovirus diseases in agriculture.
Continuous innovation is crucial to combat evolving viral threats.
These methods hold potential for sustainable crop protection against economically significant viruses.