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Capturing the Value of Vaccination within Health Technology Assessment and Health Economics-Practical Considerations
Eliana Biundo1, Mariia Dronova2, Annie Chicoye3
1GSK, Building W23, 20 Avenue Fleming, 1300 Wavre, Belgium.
Vaccines
|July 27, 2024
Summary
This study expands the value of vaccination (VoV) framework to include health systems strengthening, equity, and macroeconomic gains in cost-effectiveness analysis (CEA). Incorporating these broader benefits provides more accurate VoV assessments for decision-makers.
Area of Science:
- Health Economics
- Public Health Policy
- Vaccine Research
Background:
- The value of vaccination (VoV) framework is crucial for health technology assessment (HTA) and cost-effectiveness analysis (CEA).
- Previous frameworks identified key vaccination benefits for HTA/CEA, but broader impacts require further integration.
- Decision-makers need comprehensive methods to assess the full value of vaccination programs.
Purpose of the Study:
- To provide methods and examples for incorporating health systems strengthening (HSS), equity, and macroeconomic gains into VoV assessments.
- To demonstrate how these broader benefits influence the incremental cost-effectiveness ratio (ICER) in vaccination HTA/CEA.
- To enhance the accuracy and completeness of VoV assessments for improved decision-making.
Main Methods:
- Application of expert working groups and targeted literature reviews.
- Utilized opportunity cost methods for HSS benefits of rotavirus vaccination.
- Employed distributional CEA for health equity benefits of meningococcal vaccination and macroeconomic modeling for wider economic impacts.
Main Results:
- Including HSS benefits reduced the ICER for rotavirus vaccination by 1.4-50.5%.
- Including equity benefits for meningococcal vaccination reduced the ICER by 22-56%, with significant gains in deprived groups.
- Macroeconomic models can inform HTA processes by assessing impacts on labor force and wider economy.
Conclusions:
- Broader vaccination benefits, including HSS, equity, and macroeconomic gains, can be assessed and integrated into current HTA/CEA.
- These integrated assessments lead to more accurate and complete VoV evaluations.
- Further refinement of methods and inputs, particularly for macroeconomic gains, is recommended.
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