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Linkage analysis for psychiatric disorders. I. Basic concepts.

B K Suarez, N J Cox

    Psychiatric Developments
    |January 1, 1985
    PubMed
    Summary
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    Linkage analysis, a key tool in human genetics, is increasingly used in medicine due to more mapped polymorphic markers. This paper introduces basic linkage analysis methods for non-geneticists.

    Area of Science:

    • Human Genetics
    • Medical Genetics
    • Genomic Medicine

    Background:

    • Linkage analysis has emerged as a powerful tool in human genetics over the past decade.
    • Its utility is expanding across various medical fields, driven by advancements in genetic mapping.
    • The increasing availability of polymorphic markers is leading towards comprehensive human genome saturation.

    Purpose of the Study:

    • To provide an introductory overview of linkage analysis for a non-geneticist audience.
    • To review fundamental methodological approaches in linkage analysis.
    • To discuss the strengths, weaknesses, and underlying assumptions of these methods.

    Main Methods:

    • Review of established linkage analysis methodologies.
    • Explanation of basic principles and statistical approaches.

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  • Discussion of marker density and genome coverage.

    • Main Results:

    • Identification of key strengths and limitations of common linkage analysis techniques.
    • Outline of the assumptions inherent in applying linkage analysis.
    • Contextualization of linkage analysis within the broader field of human genetics.

    Conclusions:

    • Linkage analysis is a vital and evolving tool in modern genetics and medicine.
    • Understanding its basic methods is crucial for non-specialists.
    • Further exploration of challenges in applying linkage analysis to complex diseases is warranted.