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Serosurveillance for Measles and Rubella
Allison M Brady1, Elina El-Badry1, Eriko Padron-Regalado1
1Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Vaccines
|July 27, 2024
Summary
Measles and rubella seroprevalence varies globally, highlighting challenges in vaccination programs. Standardized serosurveys are essential for assessing population immunity and achieving disease elimination goals.
Area of Science:
- * Public Health and Epidemiology
- * Vaccinology and Immunology
Background:
- * Measles and rubella pose significant global health risks despite vaccine availability.
- * Accurate population immunity estimates are vital for disease elimination strategies.
- * Conducting effective serosurveys presents challenges, particularly in resource-limited areas.
Purpose of the Study:
- * To comprehensively review measles and rubella serosurvey studies from the past decade (2014-2024).
- * To assess methodologies, design variations, and demographic representation in published serosurveys.
- * To identify trends and disparities in population immunity against measles and rubella.
Main Methods:
- * Systematic review of 130 measles and rubella serosurvey studies published between January 2014 and January 2024.
- * Analysis of study methodologies, including sampling techniques, sample sizes, and serological assay types (predominantly IgG enzyme immunoassays).
- * Examination of population demographics, geographic distribution, and reported seroprevalence data.
Main Results:
- * Significant variability in serosurvey methodologies, sample sizes, and demographic focus across 59 countries.
- * Observed disparities in measles and rubella seroprevalence among different demographic groups, regions, migrants, and women.
- * Identified age-related antibody decline, especially in infants, and inconsistent correlations between vaccination status and seropositivity.
Conclusions:
- * Current serosurveillance practices for measles and rubella exhibit considerable heterogeneity.
- * There is a critical need for improved serosurvey design and standardization.
- * Adoption of standardized, multiplex serology assays can enhance the accuracy and efficiency of surveillance efforts.
