Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radical total pelvic exenteration with concomitant right nephrectomy in the management of recurrent endometrioid ovarian adenocarcinoma: A case report and literature review.

Clinical case reports·2024
Same author

Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca<sup>2+</sup> signaling.

Science signaling·2018
Same author

Is Parkinson's disease truly a prion-like disorder? An appraisal of current evidence.

Neurology research international·2015
See all related articles

Related Experiment Video

Updated: Jun 18, 2025

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

9.6K

Breaking Down Glioma-Microenvironment Crosstalk.

Raghavskandhan Ramachandran1, Alexander F Jeans2

  • 1Balliol College, University of Oxford, Oxford, UK.

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
|July 27, 2024
PubMed
Summary

High-grade gliomas (HGGs) are aggressive brain cancers. Understanding HGG-host brain interactions offers new therapeutic strategies for better patient outcomes.

Keywords:
glioblastomagliomahigh-grade gliomahost-glioma interactionsneurologic diseaseneurooncologysynapse

More Related Videos

Coculture System with an Organotypic Brain Slice and 3D Spheroid of Carcinoma Cells
07:48

Coculture System with an Organotypic Brain Slice and 3D Spheroid of Carcinoma Cells

Published on: October 9, 2013

20.7K
Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions
10:08

Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions

Published on: February 24, 2021

5.9K

Related Experiment Videos

Last Updated: Jun 18, 2025

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

9.6K
Coculture System with an Organotypic Brain Slice and 3D Spheroid of Carcinoma Cells
07:48

Coculture System with an Organotypic Brain Slice and 3D Spheroid of Carcinoma Cells

Published on: October 9, 2013

20.7K
Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions
10:08

Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions

Published on: February 24, 2021

5.9K

Area of Science:

  • Neuro-oncology
  • Cancer biology
  • Immunology

Background:

  • High-grade gliomas (HGGs) are the most common primary brain tumors.
  • HGGs exhibit aggressive growth and infiltration, leading to poor patient prognoses.
  • Current treatments for HGGs have limited efficacy due to their invasive nature.

Purpose of the Study:

  • To review the complex interactions between HGGs and various host brain cells.
  • To explore how these HGG-host interactions contribute to tumor progression and invasion.
  • To identify potential therapeutic targets within these interactions for novel HGG treatments.

Main Methods:

  • Literature review of recent research on HGG-host brain interactions.
  • Analysis of bidirectional communication mechanisms between HGGs and neural, glial, immune, and vascular cells.
  • Synthesis of findings to evaluate therapeutic potential.

Main Results:

  • HGGs engage in extensive bidirectional communication with neurons, glial cells, immune cells, and vascular elements.
  • These interactions actively promote tumor growth, invasion, and the tumor microenvironment.
  • Understanding these crosstalk mechanisms is crucial for developing effective therapies.

Conclusions:

  • HGG-host brain interactions are key drivers of glioma pathogenesis.
  • Exploiting these interactions presents a promising avenue for developing innovative HGG therapies.
  • Targeting the tumor microenvironment through these interactions could significantly improve patient outcomes.