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Updated: Jun 18, 2025
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Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
Published on: November 1, 2012
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Bone-muscle crosstalk under physiological and pathological conditions
Yuechao Dong1, Hongyan Yuan2, Guixing Ma3
1Department of Biochemistry, School of Medicine, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Southern University of Science and Technology, Shenzhen, 518055, China.
Cellular and Molecular Life Sciences : CMLS
|July 27, 2024
Summary
Muscle and bone closely interact through mechanical forces and signaling molecules like myokines and osteokines. Improving one benefits the other, offering strategies for skeletal and muscular health.
Area of Science:
- Biomedical Science
- Physiology
- Skeletal Muscle Biology
Background:
- Bone and muscle are anatomically connected and essential for body movement.
- Their interaction, termed mechanotransduction, involves mechanical forces and biochemical signaling (myokines, osteokines).
- Factors like metabolism, rhythm, and age influence this crosstalk, which occurs in parallel with osteogenesis and myogenesis.
Purpose of the Study:
- To review the scientific findings on bone-muscle crosstalk.
- To explore the biomechanical and biochemical coupling between muscle and bone.
- To propose strategies for improving skeletal and muscular symptoms in diseases.
Main Methods:
- Literature review of studies on bone-muscle interactions.
- Analysis of mechanotransduction pathways.
- Examination of pathological conditions involving muscle-bone defects.
Main Results:
- Bone and muscle crosstalk is crucial for osteogenesis and myogenesis.
- Defective muscles in bone diseases can lead to osteopenia and abnormal bone metabolism.
- Biomechanical and biochemical couplings mediate these pathological effects.
Conclusions:
- Functional improvements in bone or muscle positively impact the other within the motor system.
- Understanding bone-muscle crosstalk offers therapeutic potential for related diseases.
- Targeting this interaction can improve skeletal and muscular health outcomes.
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