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FUBP1 in human cancer: Characteristics, functions, and potential applications

  • 0Department of Oncology, Shaanxi Provincial People's Hospital, No 256 Youyi West Road, Xi'an, 710068, Shaanxi, China.
Translational Oncology +

|

July 27, 2024

|

July 27, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Far upstream element-binding protein 1 (FUBP1) has dual roles in cancer, acting as both an oncogene and a tumor suppressor. Understanding its context-dependent functions is key for developing targeted FUBP1 cancer therapies.

Area Of Science

  • Molecular Biology
  • Oncology
  • Biochemistry

Background

  • Far upstream element-binding protein 1 (FUBP1) is a nucleic acid-binding protein regulating DNA transcription, RNA biogenesis, and translation.
  • Aberrant FUBP1 expression and mutations are linked to various cancers, often indicating oncogenic roles.
  • Emerging research suggests a context-dependent, tissue-specific tumor-suppressive function for FUBP1.

Purpose Of The Study

  • To review the association between FUBP1 and diverse cancers.
  • To discuss the multifaceted functions of FUBP1 in tumorigenesis.
  • To explore potential clinical implications and future research directions for FUBP1-targeted therapies.

Main Methods

  • Literature review of studies on FUBP1 in cancer.
  • Analysis of FUBP1's roles in different cancer types.
  • Synthesis of current understanding of FUBP1's oncogenic and tumor-suppressive functions.

Main Results

  • FUBP1 overexpression is frequently associated with oncogenic activity across various tumors.
  • Evidence indicates a tumor-suppressive role for FUBP1 in specific cancer contexts.
  • The dual role of FUBP1 is complex and appears to be tissue- and context-dependent.

Conclusions

  • FUBP1 presents a complex role in cancer, acting as both an oncoprotein and a tumor suppressor.
  • Further research is needed to elucidate the precise mechanisms and tissue-specific functions of FUBP1.
  • Targeting FUBP1 may offer novel therapeutic strategies, but requires careful consideration of its dual roles.

Keywords:

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