Mitochondrial function in oral health and disease
Ana Carolina Morandini1, Erivan S Ramos-Junior2
1Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia at Augusta University, Augusta, GA, USA; Department of Periodontics, Dental College of Georgia at Augusta University, Augusta, GA, USA.
Journal of Immunological Methods
|July 27, 2024
Summary
Monitoring mitochondrial function and quality control is key to understanding aging diseases. This review focuses on oral health, particularly periodontal inflammation, and methods to assess mitochondrial health.
Area of Science:
- Mitochondrial biology
- Oral health research
- Aging and disease
Background:
- Mitochondrial dysfunction is implicated in aging-related diseases like inflammation and neurodegeneration.
- Assessing mitochondrial health is vital for understanding cellular dysfunction.
- Periodontal disease is an age-associated inflammatory condition impacting the elderly population.
Purpose of the Study:
- To review current evidence on mitochondrial function and quality control in oral health and disease.
- To provide a perspective on mitochondrial assessment in periodontal inflammation.
- To highlight the significance of mitochondrial health in oral disease pathophysiology.
Main Methods:
- Review of existing literature on mitochondrial assessment techniques.
- Focus on methods evaluating mitochondrial dynamics, mitophagy, and biogenesis.
- Inclusion of assessments for oxidative stress, electron transport chain function, and metabolomics.
Main Results:
- Mitochondrial assessment approaches offer insights into cellular homeostasis.
- Understanding mitochondrial roles is crucial for oral disease implications.
- Latest evidence links mitochondrial function to periodontal inflammation.
Conclusions:
- Monitoring mitochondrial function and quality control is essential for understanding oral health and disease.
- Mitochondrial assessment methods are valuable tools for periodontal disease research.
- This review provides a framework for future research on mitochondria in oral inflammatory conditions.
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