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Related Experiment Video

Updated: Jun 20, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Reduced response to regadenoson with increased weight: An artificial intelligence-based quantitative myocardial

Emmanouil Androulakis¹, Georgios Georgiopoulos², Alessia Azzu¹

¹Royal Brompton and Harefield Hospitals, Guy's & St Thomas' NHS Foundation Trust, London, UK.

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance

|July 27, 2024

Summary

Fixed-dose regadenoson may be inadequate for patients with high body weight, leading to reduced myocardial perfusion. Weight-adjusted stressors like adenosine may be a better alternative for these individuals.

Keywords:

Adenosine Cardiovascular magnetic resonance Quantitative perfusion Regadenoson Weight

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Last Updated: Jun 20, 2026

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Published on: February 16, 2016

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Area of Science:

Cardiology
Medical Imaging
Pharmacology

Background:

Conflicting evidence exists on regadenoson efficacy in high body weight patients.
Quantitative cardiovascular magnetic resonance (CMR) perfusion parameters offer novel insights.

Purpose of the Study:

Evaluate regadenoson effectiveness across varying body weights using quantitative CMR.
Compare regadenoson with adenosine stress in patients with coronary artery disease risk factors.

Main Methods:

Utilized a dual-sequence quantitative CMR perfusion protocol with AI-generated parameters.
Administered a fixed 0.4 mg regadenoson dose to 217 patients.
Compared results with 218 patients undergoing adenosine stress perfusion.

Main Results:

Found an inverse association between weight and myocardial perfusion reserve with regadenoson (P=0.045).
Increased weight correlated with higher odds of inadequate stress response (OR=1.36, P=0.005).
High weight (>93 kg) or BSA (>2.06 m²) significantly increased odds for inadequate regadenoson response (ORs ~8).

Conclusions:

A fixed regadenoson dose may not achieve maximal hyperemia in heavier patients.
Quantitative CMR reveals an inverse relationship between weight and regadenoson response.
Consider weight-adjusted stressors like adenosine for patients >93 kg or BSA >2.06 m².