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Published on: January 7, 2019
Development of magnesium hydroxide-doped nanofibrous spheres for repairing infected skin wounds
Yong You1, Xuchao Ning2, Xiaopei Zhang3
1The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao 266000, China.
Abstract:
The healing of skin wounds is a continuous and coordinated process, typically accompanied by microbial colonization and growth. This may result in wound infection and subsequent delay in wound healing. Therefore, it is of particular importance to inhibit the growth of microorganisms in the wound environment. In this study, magnesium hydroxide-doped polycaprolactone (PCL/MH) nanofibrous spheres were fabricated by electrospinning and electrospray techniques to investigate their effects on infected wound healing. The prepared PCL/MH nanofibrous spheres had good porous structure and biocompatibility, providing a favorable environment for the delivery and proliferation of adipose stem cells. The incorporation of MH significantly enhanced the antimicrobial properties of the spheres, in particular, the inhibition of the growth of S. aureus and E. coli. We showed that such PCL/MH nanofibrous spheres had good antimicrobial properties and effectively promoted the regeneration of infected wound tissues, which provided a new idea for the clinical treatment of infected wounds.
Insights
Magnesium hydroxide-doped polycaprolactone (PCL/MH) nanofibrous spheres effectively inhibit bacterial growth and promote infected wound healing. This study presents a novel approach for treating challenging skin wounds by enhancing tissue regeneration and antimicrobial properties.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing
Background:
- Skin wound healing is a complex process often complicated by microbial colonization, leading to infection and delayed healing.
- Inhibiting microbial growth in wound environments is crucial for effective treatment and tissue regeneration.
- Current treatments face challenges in managing infected wounds and promoting optimal healing outcomes.
Purpose of the Study:
- To fabricate and evaluate magnesium hydroxide-doped polycaprolactone (PCL/MH) nanofibrous spheres for infected wound healing.
- To assess the antimicrobial efficacy of PCL/MH nanofibrous spheres against common wound pathogens.
- To investigate the potential of PCL/MH nanofibrous spheres in promoting infected wound tissue regeneration.
Main Methods:
- Fabrication of PCL/MH nanofibrous spheres using electrospinning and electrospray techniques.
- Characterization of the porous structure and biocompatibility of the PCL/MH spheres.
- In vitro assessment of antimicrobial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli).
- In vivo evaluation of the efficacy of PCL/MH spheres in promoting infected wound healing and tissue regeneration.
Main Results:
- The PCL/MH nanofibrous spheres exhibited a favorable porous structure and excellent biocompatibility.
- Incorporation of magnesium hydroxide significantly enhanced the antimicrobial properties of the PCL/MH spheres.
- PCL/MH spheres demonstrated potent inhibition of S. aureus and E. coli growth.
- The PCL/MH nanofibrous spheres effectively promoted the regeneration of infected wound tissues.
Conclusions:
- PCL/MH nanofibrous spheres possess significant antimicrobial properties beneficial for infected wound management.
- These spheres provide a promising platform for delivering therapeutic agents and supporting adipose stem cell proliferation.
- The developed PCL/MH nanofibrous spheres offer a novel strategy for enhancing infected wound healing and tissue regeneration.
