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Related Experiment Video

Updated: Jun 18, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

Updates in Pediatric Sickle Cell Lung Disease.

Michelle Gillespie¹, Olufunke Afolabi-Brown², Evans Machogu³

¹Division of Pulmonary Medicine, The Ohio State University Wexner Medical Center, Nationwide Children's Hospital, 2050 Kenny Road, Suite 2200, Columbus, OH, USA.

Clinics in Chest Medicine

|July 28, 2024

Summary

Sickle cell lung disease in children involves complex airway and breathing issues. Further research is needed for effective treatments and to understand long-term outcomes.

Keywords:

Acute chest syndrome Asthma Pollution Pulmonary hypertension Sleep

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Last Updated: Jun 18, 2025

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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

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Published on: March 14, 2017

Area of Science:

Pulmonary Medicine
Pediatric Hematology

Background:

Sickle cell lung disease (SCD) presents a complex clinical challenge.
It encompasses acute and chronic lower airway disease, sleep-disordered breathing, and pulmonary vascular disease.
Environmental factors significantly modify disease presentation.

Purpose of the Study:

To highlight the essential understanding of presentation, pathophysiology, and diagnostics for accurate identification and management of sickle cell lung disease.
To underscore the need for research into effective treatments and interventions to reduce disease burden in affected children.
To identify the unknown long-term impact of interventions on cardiopulmonary outcomes.

Main Methods:

Review of current understanding of sickle cell lung disease.
Analysis of existing diagnostic approaches.
Identification of research gaps and future directions.

Main Results:

Sickle cell lung disease involves multifaceted pulmonary complications.
Accurate diagnosis and management require a comprehensive understanding of pathophysiology.
Current treatment strategies require further development and evaluation.

Conclusions:

Significant progress has been made, but effective treatments for sickle cell lung disease are still needed.
The long-term effects of interventions on cardiopulmonary health in children with sickle cell disease remain largely unknown.
Collaborative efforts are crucial for improving care and outcomes for children with sickle cell lung disease.