Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

113
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
113
Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

321
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
321
Sedatives and Hypnotics Drugs: Benzodiazepines01:19

Sedatives and Hypnotics Drugs: Benzodiazepines

227
Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
227
Sedatives and Hypnotics Drugs: Barbiturates01:20

Sedatives and Hypnotics Drugs: Barbiturates

231
Sedatives and hypnotics encompass a drug class that acts on the central nervous system (CNS) to alleviate anxiety, promote relaxation and induce sleep.These drugs function by amplifying the actions of the neurotransmitter γ-aminobutyric acid (GABA), resulting in reduced neuronal activity. Barbiturates, a subset of sedatives and hypnotics first synthesized in the late 1800s, are categorized into ultra-short, short, intermediate, and long-acting groups based on their duration of effect. A...
231
Stages of General Anesthesia01:22

Stages of General Anesthesia

404
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
404
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

242
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
242

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes and Prognostic Factors of Auto-Transplanted Immature Third Molars: A 15-Year Retrospective Cohort Study.

International dental journal·2026
Same author

2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 7. Pediatric basic life support.

Clinical and experimental emergency medicine·2026
Same author

2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 8. Pediatric advanced life support.

Clinical and experimental emergency medicine·2026
Same author

Characterization and Evaluation of Biological Properties of Calcium Silicate Cement-based Sealers after Thermal Pretreatment.

Journal of endodontics·2026
Same author

Academic burden and coping among Generation Z Korean nursing students: a focus group study.

BMC medical education·2026
Same author

An Emerging Role of Artificial Intelligence in Pediatric Neuroanesthesia.

Journal of Korean Neurosurgical Society·2026

Related Experiment Video

Updated: Jun 18, 2025

Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

17.5K

Effective and safe pediatric sedation.

Young-Eun Jang1, Jin-Tae Kim1

  • 1Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Anesthesia and Pain Medicine
|July 29, 2024
PubMed
Summary
This summary is machine-generated.

Pediatric sedation safely manages pain and anxiety in children during medical procedures. A comprehensive strategy involving careful evaluation, skilled professionals, and vigilant monitoring ensures successful outcomes and minimizes risks.

Keywords:
ComplicationsHypnotics and sedativesMonitoringPatient safetyPediatricProcedural sedation.

More Related Videos

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
15:18

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

18.2K
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

2.7K

Related Experiment Videos

Last Updated: Jun 18, 2025

Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

17.5K
Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
15:18

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

18.2K
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

2.7K

Area of Science:

  • Medical Science
  • Pediatrics
  • Anesthesiology

Background:

  • Pediatric sedation is essential for managing procedural pain and anxiety in children.
  • Despite its benefits, pediatric sedation carries inherent risks that necessitate careful management.

Purpose of the Study:

  • To provide a comprehensive review of pediatric sedation practices.
  • To highlight established methods and recent advancements in the field.
  • To emphasize strategies for ensuring patient safety and minimizing complications.

Main Methods:

  • Review of established practices and recent advancements in pediatric sedation.
  • Discussion of pre-procedural evaluation protocols.
  • Analysis of pharmacological and non-pharmacological sedation approaches.
  • Emphasis on multidisciplinary team collaboration and vigilant monitoring.

Main Results:

  • Thorough pre-procedural evaluation is critical for risk mitigation.
  • The selection of sedative medications is dependent on procedure type and patient condition.
  • Non-pharmacological methods can supplement pharmacological sedation.
  • A multidisciplinary approach with vigilant monitoring is key to preventing complications.

Conclusions:

  • Successful pediatric sedation requires a holistic strategy.
  • Key components include comprehensive evaluation, skilled personnel, appropriate medication, and continuous monitoring.
  • Adherence to these principles minimizes risks and optimizes patient outcomes.