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Related Experiment Video

Updated: Jun 18, 2025

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

Cardiovascular Health Starts in the Womb.

Bonita Falkner^1,2, Barbara T Alexander³, Anne-Monique Nuyt⁴

¹Departments of Medicine (B.F.), Sydney Kimmel College of Medicine, Thomas Jefferson University, Philadelphia, PA.

Hypertension (Dallas, Tex. : 1979)

|July 29, 2024

Summary

This summary is machine-generated.

Childhood hypertension is now recognized, with definitions evolving since the 1970s. Research links early life factors, like low birth weight, to adult cardiovascular disease risk.

Keywords:

adolescent adult birth weight blood pressure hypertension pre-eclampsia risk factors

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In utero Measurement of Heart Rate in Mouse by Noninvasive M-mode Echocardiography

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Published on: November 22, 2013

Area of Science:

Cardiovascular Science
Pediatric Health
Epidemiology

Background:

Hypertension was historically considered an adult disorder, with blood pressure (BP) not routinely measured in children.
Childhood BP levels are lower than adults', vary with age and growth, necessitating distinct hypertension definitions.
The 95th percentile of BP levels in children and adolescents became the epidemiological definition for hypertension.

Purpose of the Study:

To review recent findings on maternal and offspring conditions linked to cardiovascular disease risk.
To explore the childhood origins of hypertension, building on the Barker hypothesis.
To examine data from longitudinal maternal-child cohorts and experimental models.

Main Methods:

Review of longitudinal maternal-child cohort studies.
Analysis of experimental models investigating cardiovascular disease origins.
Epidemiological and clinical research on childhood hypertension and risk factors.

Main Results:

Childhood BP levels are age and growth-related, requiring specific definitions.
Childhood risk factors for hypertension have been identified, linking youth BP to adult hypertension.
The Barker hypothesis highlighted low birth weight's connection to adult cardiovascular disease.

Conclusions:

Understanding childhood origins of hypertension is crucial for preventing adult cardiovascular disease.
Maternal and offspring conditions during development significantly impact future cardiovascular health.
Continued research in maternal-child health and experimental models is vital for cardiovascular disease prevention.