Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation
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Updated: Jun 18, 2025

Dynamic Proteomic and miRNA Analysis of Polysomes from Isolated Mouse Heart After Langendorff Perfusion
Published on: August 29, 2018
Shijie Liu1,2,3, Vaibhav Deshmukh4, Fangfei Wang3
1Cardiomyocyte Renewal Laboratory, Texas Heart Institute, Houston, Texas, USA.
Abstract:
Gene expression involves transcription, translation, and mRNA and protein degradation. Advanced RNA sequencing measures mRNA levels for cell state assessment, but mRNA level does not fully reflect protein level. Identifying heart cell proteomes and their stress response is crucial. Using a cardiomyocyte-specific mouse model, we tracked protein synthesis after myocardial infarction. Our results showed that myocardial infarction suppresses protein synthesis and unveils a decoupling of translation and transcription regulation in cardiomyocytes.
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