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Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
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Related Experiment Video

Updated: Jun 18, 2025

Author Spotlight: Rehabilitation of Stroke Patients With a Digital Occupational Training System
07:35

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Hyperbaric Oxygen Post Established Stroke.

David W Harrison1, Penny M Brasher2, Janice J Eng3

  • 1Emergency Medicine/Hyperbaric Medicine, Vancouver General Hospital/University of British Columbia, Vancouver, CAN.

Cureus
|July 29, 2024
PubMed
Summary
This summary is machine-generated.

Hyperbaric oxygen therapy (HBOT) did not show significant neurological benefits for chronic stroke survivors in this trial. The study found no clinically important improvement on the Stroke Impact Scale-16, questioning HBOT

Keywords:
hyperbarichyperbaric oxygenischemic strokeoxygenrehabilitationstrokestroke recoverystroke rehabilitation

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Hyperbaric Medicine

Background:

  • Previous research suggested hyperbaric oxygen therapy (HBOT) may improve neurological function in chronic stroke survivors.
  • A prior single trial indicated potential benefits but lacked a sham control group and had other limitations.

Purpose of the Study:

  • To evaluate the effectiveness of HBOT compared to a sham control in adults experiencing chronic effects of ischemic stroke.
  • To assess HBOT's impact on neurological function, balance, cognition, and mood in stroke survivors.

Main Methods:

  • A single-center, parallel-group, randomized trial was conducted with adults 6-36 months post-ischemic stroke.
  • The study initially included a sham control arm, later modified to a waitlist control due to recruitment challenges.
  • Participants received 40 sessions of either HBOT or sham treatment, with the Stroke Impact Scale-16 as the primary outcome.

Main Results:

  • The trial enrolled only 34 participants, falling short of the target sample size of 68 per arm, and was stopped early due to low recruitment.
  • At the end of treatment, the sham group showed a statistically significant, though small, improvement in the Stroke Impact Scale-16 compared to the HBOT group (difference of 5.5).
  • Secondary outcome measures also did not demonstrate significant benefits favoring HBOT.

Conclusions:

  • The study results exclude a clinically significant benefit of HBOT on the primary outcome measure (SIS-16) in chronic stroke survivors.
  • These findings do not support the use of hyperbaric oxygen therapy for rehabilitation in individuals with chronic stroke.
  • Further research with improved recruitment strategies may be needed, but current evidence does not favor HBOT for this patient population.