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Updated: May 10, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
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Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

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Tacrolimus-Induced Recurrent Acute Coronary Syndrome Due to an Unknown Mechanism

Sebastian L Manuel1, Jenna Sapone1, Frank Lin1

  • 1Internal Medicine, St. Luke's Hospital, Easton, USA.

Cureus
|July 29, 2024
PubMed

Tacrolimus, a potent immunosuppressive agent widely used in solid organ transplantation, has been associated with numerous harmful side effects. We report an interesting case of a patient who is status post liver transplantation and who has been maintained on tacrolimus for the past 10 years. She presented in the hospital with a ST-segment elevation myocardial infarction (STEMI), with normal coronary angiography. The patient was found to have a markedly elevated tacrolimus level. After decreasing the dose of tacrolimus and starting isosorbide mononitrate, the patient's symptoms resolved, and the patient had no recurrence of symptoms.

Keywords:
acute coronary syndromechest painelevated troponintacrolimusvasospasm

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