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Updated: Jun 18, 2025

DNA Vector-based RNA Interference to Study Gene Function in Cancer
Published on: June 4, 2012
Protumorigenic Interferon-Stimulated Genes in Cancer: A Comprehensive Review
Danial Qasim Butt1, Masitah Hayati Harun1, Nur Asyilla Che Jalil2
1Oral Medicine and Oral Pathology Unit, School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS.
Abstract:
Interferon-stimulated genes (ISGs), whose production is triggered by interferons, are known to defend the host from pathogenic and cancer-specific antigens, one of which is by inducing apoptosis in infected or mutated cells. It has been reported recently that specific ISGs aid cancer cells in evading immunosurveillance and inflammatory cells by inhibiting the apoptosis process. This report reviewed four apoptosis-regulating ISG proteins: interferon-stimulated gene 15 (ISG15), interferon alpha-inducible protein 27 (IFI27), interferon alpha-inducible protein 6 (IFI6), and radical S-adenosyl methionine domain containing 2 (RSAD2), demonstrating anti-apoptosis function, and considered them protumorigenic.
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