Related Experiment Video

Updated: Jun 20, 2026

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
15:18

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

18.2K

The Ross Procedure in Children and Infants: A Systematic Review With Pooled Analyses

Nabil Dib1,2, Walid Ben Ali1, Thierry Ducruet3

  • 1Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, Québec, Canada.

CJC Pediatric and Congenital Heart Disease
|July 29, 2024
PubMed

Insights

The Ross procedure offers modest survival rates in children with congenital aortic stenosis. However, infants undergoing this surgery face significantly higher mortality and reintervention risks, highlighting the need for careful consideration.

Area of Science:

  • Pediatric Cardiac Surgery
  • Congenital Heart Disease
  • Aortic Valve Replacement

Background:

  • The Ross procedure is a surgical option for congenital aortic stenosis, replacing the aortic valve with a pulmonary autograft.
  • Outcomes in children, especially infants, following the Ross procedure are not well-established.

Purpose of the Study:

  • To systematically review and analyze survival and reintervention rates after the Ross procedure in children.
  • To specifically evaluate outcomes in infants (younger than 1 year) compared to older children.

Main Methods:

  • Systematic review and pooled analysis of 25 studies including 2737 patients, adhering to PRISMA criteria.
  • Extraction of inferred individual patient data from life tables to assess primary endpoints: early (≤30 days) and late (>30 days) mortality.
  • Secondary endpoints included freedom from reintervention for the right ventricular outflow tract and pulmonary autograft, with sensitivity analyses for infants.

Main Results:

  • Overall pooled early survival was 96.0%, but significantly lower at 86.8% for infants.
  • Pooled 10-year survival was 91.1% overall and 79.3% for infants.
  • Infants had substantially higher mortality (HR: 3.38) and reintervention rates (51.2% for RVOT) compared to non-infant children, with younger age strongly linked to poorer outcomes.

Conclusions:

  • The Ross procedure demonstrates modest survival and autograft reoperation rates in the pediatric population.
  • Infancy is a critical factor associated with significantly poorer survival and increased reintervention rates following the Ross procedure.
Abstract

More Related Videos

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling07:11

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Published on: February 5, 2019

9.0K
A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn11:27

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn

Published on: April 7, 2023

6.2K

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...