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Related Experiment Video

Updated: May 5, 2026

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel
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Ceftaroline-Induced Thrombocytopenia: A Case Report.

Diego Ortiz-Mendiguren1, Ian Crespo-Orta1, Mark Miranda-Márquez2

  • 1Internal Medicine, Veterans Affairs Caribbean Healthcare System, San Juan, PRI.

Cureus
|July 29, 2024
PubMed
Summary

Ceftaroline can cause severe drug-induced thrombocytopenia, a dangerous drop in platelet count. Prompt recognition and intervention are crucial for patient safety, especially in those on anticoagulation therapy.

Keywords:
abruptantibioticceftarolinedrugdrug-induced immune thrombocytopeniaimmuneinducedseverethrombocytopenia

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Area of Science:

  • Pharmacology
  • Hematology
  • Clinical Medicine

Background:

  • Drug-induced thrombocytopenia (DIT) is a rare adverse drug reaction.
  • It can lead to severe bleeding, thrombosis, and mortality.
  • Ceftaroline is a fifth-generation cephalosporin antibiotic.

Observation:

  • A 69-year-old male patient with atrial fibrillation on rivaroxaban developed severe thrombocytopenia.
  • The patient had a history of allergies to amoxicillin and sulfa drugs.
  • Ceftaroline was initiated for left lower extremity purulent cellulitis.

Findings:

  • The patient's platelet count rapidly decreased from 204,000 to 4,000 x 10³/μL within 24 hours of ceftaroline initiation.
  • This severe drop in platelets occurred despite the patient being on anticoagulation therapy (rivaroxaban).

Implications:

  • This case underscores the critical importance of recognizing ceftaroline-induced thrombocytopenia.
  • Prompt diagnosis and management are essential to prevent life-threatening complications such as major bleeding.
  • Clinicians should maintain a high index of suspicion for DIT in patients presenting with sudden thrombocytopenia, particularly when initiating new medications.