Research Progress of Disulfide Bond Based Tumor Microenvironment Targeted Drug Delivery System

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Chemotherapy faces challenges like toxicity and poor drug properties.
• Targeted drug delivery systems are crucial for effective cancer treatment.
• Tumor microenvironment-responsive nanomedicine offers a promising solution.

Purpose of the Study:

• To review disulfide bond-based drug delivery systems (DDS) for cancer therapy.
• To analyze DDS targeting the tumor microenvironment.
• To discuss clinical applicability and challenges of these DDS.

Main Methods:

• Focus on nanomedicine delivery systems utilizing disulfide bonds.
• Analysis of DDS incorporating pH-responsive carriers and tumor-targeting ligands.
• Review of drug loading strategies, carrier design, and controlled release mechanisms.

Main Results:

• Disulfide bonds enable reduction-sensitive drug release in response to high glutathione (GSH) levels.
• Combined strategies (pH-responsive, ligand-targeting) enhance DDS precision.
• Various DDS designs demonstrate controlled release and potential for improved therapeutic outcomes.

Conclusions:

• Disulfide bond-based DDS show significant potential for targeted cancer therapy.
• Further research and development are needed to overcome clinical translation challenges.
• These advanced DDS offer a promising avenue for improving chemotherapy efficacy and patient safety.