Prognostic model development and clinical correlation of eight key genes in skin cutaneous melanoma

Cutaneous melanoma (SKCM) is a challenging and increasingly prevalent cancer with limited effective treatments. In our extensive study of 342 SKCM samples, we developed a prognostic model identifying eight key genes-CASPASE7CLEAVEDD198, FOXO3A, Melanoma gp100, CD171, 1433ZETA, SRC, P21, and CABL-linked to SKCM prognosis. Statistical analysis indicated significant differences in clinical outcomes between low and high-risk groups, corroborated by principal component analysis (PCA). Survival analysis and receiver operating characteristic (ROC) curve analysis confirmed the model's predictive accuracy for SKCM prognosis. Additionally, we observed notable correlations between the expression levels of genes related to prognosis and clinical characteristics. Our research offers crucial insights into SKCM prognosis, suggesting potential diagnostic markers and personalized treatment targets.