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Prostate cancer recurrence in the urethra with low PSA
Shravankrishna Ananthapadmanabhan1, Zoe Williams1, Henry Wang1
1Nepean Urology Research Group, Nepean Hospital, Kingswood, New South Wales, 2747, Australia.
Urology Case Reports
|July 29, 2024
Summary
Prostate cancer recurrence is rare in the urethra, even years after treatment. This case shows that new urinary symptoms after prostatectomy warrant investigation for rare recurrences.
Area of Science:
- Urology
- Oncology
Background:
- Prostate cancer recurrence typically occurs in predictable sites like the pelvic lymph nodes or liver.
- Urethral metastasis is an exceptionally rare presentation of prostate cancer recurrence.
Observation:
- An 82-year-old male presented with new lower urinary tract symptoms 10 years post-robotic radical prostatectomy.
- His prostate-specific antigen (PSA) level was very low at 0.05μg/L.
Findings:
- The patient was diagnosed with urethral recurrence of prostate cancer.
- This represents an exceedingly rare site for metastasis after prostatectomy.
Implications:
- Clinicians should consider prostate cancer recurrence in patients with late-onset or changing lower urinary tract symptoms post-prostatectomy.
- Maintaining a high index of suspicion is crucial for diagnosing rare metastatic sites like urethral recurrence.
