Association between body mass index combined with high-sensitivity C-reactive protein and the risk of postmenopausal breast cancer: A prospective cohort study
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.High body mass index (BMI) and high high-sensitivity C-reactive protein (hs-CRP) levels significantly increase postmenopausal breast cancer risk. This finding highlights the combined impact of obesity and inflammation on cancer development.
Area Of Science
- Oncology
- Epidemiology
- Biomarkers
Background
- Obesity, indicated by body mass index (BMI), is a known risk factor for postmenopausal breast cancer.
- Chronic inflammation, often measured by high-sensitivity C-reactive protein (hs-CRP), may also contribute to cancer development.
- The combined effect of BMI and hs-CRP on postmenopausal breast cancer risk requires further investigation.
Purpose Of The Study
- To assess the association between combined body mass index (BMI) and high-sensitivity C-reactive protein (hs-CRP) levels and the risk of postmenopausal breast cancer.
- To stratify participants into distinct groups based on BMI and hs-CRP levels to identify high-risk populations.
- To provide evidence for potential combined risk assessment strategies for postmenopausal breast cancer.
Main Methods
- Prospective cohort study within the Kailuan Study involving 19,540 postmenopausal women.
- Participants categorized into four groups based on BMI (≥24 kg/m² vs. <24 kg/m²) and hs-CRP levels (≥3 mg/L vs. <3 mg/L).
- Cox proportional hazards models utilized to evaluate the association between combined BMI and hs-CRP levels and incident postmenopausal breast cancer over a median follow-up of 14.97 years.
Main Results
- A total of 269 cases of postmenopausal breast cancer were diagnosed during the follow-up period.
- Women with both high BMI (≥24 kg/m²) and high hs-CRP (≥3 mg/L) exhibited a significantly increased risk of postmenopausal breast cancer.
- The hazard ratio for postmenopausal breast cancer in the high BMI and high hs-CRP group was 1.75 (95% CI, 1.25-2.47) compared to the low BMI and low hs-CRP group.
- Sensitivity analyses confirmed the primary findings, indicating robustness of the results.
Conclusions
- The combination of high body mass index and elevated high-sensitivity C-reactive protein levels is associated with a substantially increased risk of developing postmenopausal breast cancer.
- This study underscores the importance of considering both obesity and inflammatory markers for a comprehensive risk assessment of postmenopausal breast cancer.
- Findings from the Kailuan Study suggest that interventions targeting weight management and inflammation may be beneficial in reducing postmenopausal breast cancer incidence.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...