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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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  1. Home
  3. Bcar3 And Bcar3-related Competing Endogenous Rna Expression In Hepatocellular Carcinoma And Their Prognostic Value.
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  3. Bcar3 And Bcar3-related Competing Endogenous Rna Expression In Hepatocellular Carcinoma And Their Prognostic Value.

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BCAR3 and BCAR3-related competing endogenous RNA expression in hepatocellular carcinoma and their prognostic value.

Hui-Qin Shi1, Shu Huang2,3, Xin-Yue Ma1

  • 1Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.

World Journal of Gastrointestinal Oncology
|July 29, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

BCAR3 gene overexpression is linked to poor prognosis in hepatocellular carcinoma (HCC). Targeting BCAR3 may offer new therapeutic strategies for HCC patients.

Keywords:
BioinformaticsBreast cancer anti-estrogen-resistant protein 3Hepatocellular carcinomaImmunoassayPrognosis

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Hepatocellular carcinoma (HCC) presents a significant global health challenge due to high incidence and mortality.
  • The precise molecular mechanisms driving HCC development are not fully understood, though abnormal gene expression is implicated.
  • While BCAR3 is overexpressed in various cancers, its specific role in HCC remains largely uncharacterized.

Purpose of the Study:

  • To investigate the expression patterns of BCAR3 and its related competing endogenous RNAs (ceRNAs) in HCC.
  • To evaluate the clinical significance of BCAR3 and its ceRNA network in HCC.
  • To identify potential new diagnostic and therapeutic targets for HCC.

Main Methods:

  • Utilized transcriptome and clinical data from The Cancer Genome Atlas and The Genotype Tissue Expression databases for HCC.
  • Employed multiple bioinformatics databases (UALCAN, Timer 2.0, cBioPortal, LinkedOmics, starBase) for comprehensive analysis.
  • Performed survival analysis (Kaplan-Meier, Cox regression), correlation analysis with immune functions, and functional enrichment analysis (GO, KEGG).

    • Main Results:

    • BCAR3 is differentially expressed in tumor tissues and its overexpression serves as an unfavorable prognostic indicator in HCC.
    • BCAR3 overexpression correlates with adverse cytogenetic risk, gene mutations, and positive associations with most immune cells.
    • Functional enrichment revealed BCAR3's involvement in EGFR and ERBB signaling pathways, DNA replication, and GTPase regulator activity, with RAB30-DT and miR-19b-3p pathways implicated in HCC development.

    Conclusions:

    • BCAR3 plays a role in the occurrence and development of HCC.
    • BCAR3 may represent a novel biomarker and therapeutic target for hepatocellular carcinoma.
    • Further research is warranted to elucidate the specific mechanisms underlying BCAR3's function in HCC.