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Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Proteomics01:33

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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  9. Predictive And Prognostic Markers
  11. Comprehensive Serum Proteomics Profiles And Potential Protein Biomarkers For The Early Detection Of Advanced Adenoma And Colorectal Cancer.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Comprehensive Serum Proteomics Profiles And Potential Protein Biomarkers For The Early Detection Of Advanced Adenoma And Colorectal Cancer.

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Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
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Comprehensive serum proteomics profiles and potential protein biomarkers for the early detection of advanced adenoma and colorectal cancer.

Chang Tan1, Geng Qin2, Qian-Qian Wang1

  • 1Graduate School, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China.

World Journal of Gastrointestinal Oncology
|July 29, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

This study identified serum protein biomarkers for early colorectal cancer (CRC) and advanced adenoma (AA) detection. LBP and VASP show promise for screening, aiding in the early diagnosis of these conditions.

Keywords:
Advanced adenomaColorectal cancerEarly screeningProtein biomarker

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Area of Science:

  • Proteomics
  • Biomarker Discovery
  • Cancer Research

Background:

  • Colorectal cancer (CRC) often develops from advanced adenomas (AA).
  • Serum protein biomarkers offer potential for early AA and CRC detection.
  • Proteomics technologies are advancing early screening capabilities.

Purpose of the Study:

  • To identify novel serum protein biomarkers for the early screening of advanced adenoma (AA) and colorectal cancer (CRC).

Main Methods:

  • Quantitative proteomic analysis using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) on 43 serum samples (8 normal controls, 19 AA, 16 CRC).
  • Identification of differentially expressed proteins (DEPs) with P < 0.05 and fold change > 1.5.
  • Bioinformatics analysis, prognostic analysis using public databases, and immunohistochemical validation.
Serum proteomics

Main Results:

  • Identified 2132 proteins and 17365 peptides.
  • Found significant differences in protein expression between normal controls, AA, and CRC groups.
  • Highlighted LBP and VASP as potential biomarkers for early colorectal tumor screening, with VASP, LBP, TUBGCP5, and DOK3 associated with poor prognosis.

Conclusions:

  • Elucidated serum proteomic profiles in AA and CRC patients.
  • Identified LBP and VASP as promising candidates for early AA and CRC detection.
  • Protein biomarkers can significantly contribute to the early diagnosis of colorectal tumors.