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Triglyceride-Glucose Index as a Predictor of Major Adverse Cardiovascular Events in Post-PCI Patients Diagnosed with
Yi-Fei Wang1, Xiao-Han Kong1, Hui-Min Tao2
1Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210000, People's Republic of China.
Insights
The triglyceride-glucose (TyG) index predicts major adverse cardiovascular events (MACEs) in patients with in-stent restenosis after PCI. Higher TyG index levels indicate increased MACE risk, especially in males with diabetes.
Area of Science:
- Cardiology
- Metabolic Syndrome
- Cardiovascular Disease Biomarkers
Background:
- The triglyceride-glucose (TyG) index is a recognized predictor of outcomes in coronary artery disease (CAD) patients post-percutaneous coronary intervention (PCI).
- The prognostic value of the TyG index specifically for patients experiencing in-stent restenosis (ISR) remains underexplored.
Purpose of the Study:
- To investigate the association between the TyG index and the incidence of major adverse cardiovascular events (MACEs).
- To evaluate the TyG index as a predictive biomarker for MACEs in patients with ISR following PCI.
Main Methods:
- A retrospective analysis of 1654 patients who underwent PCI between 2016 and 2022.
- Patients were categorized into three groups based on TyG index quantiles.
- The TyG index was calculated using the formula: Ln (triglycerides [mg/dL] × fasting plasma glucose [mg/dL]/2).
Main Results:
- Patients in the highest TyG index group exhibited a significantly increased risk of MACEs compared to the lowest group (HR 1.60; P = 0.01).
- Each standard deviation increase in the TyG index correlated with higher MACE risk (HR 1.51; P = 0.01).
- This association was more pronounced in male and diabetic patient subgroups, and a heightened risk of MACEs was observed at 6 months post-PCI for the highest TyG index group.
Conclusions:
- An elevated TyG index is linked to a greater risk of adverse cardiovascular events in patients with ISR.
- The predictive value of the TyG index for MACEs is particularly significant in male patients with diabetes.
Background:
The triglyceride-glucose index (TyG) is a reliable indicator for predicting the prognosis of patients with coronary heart disease (CAD) after percutaneous coronary intervention (PCI). However, its influence on patients with in-stent restenosis (ISR) is unclear. This study was designed to evaluate the association between the TyG index and the occurrence of major adverse cardiovascular events (MACEs) after PCI in patients with ISR.
Methods:
This retrospective study included 1654 patients who underwent PCI between 2016 and 2022 at Nanjing First Hospital. Patients were stratified into three groups based on the quantile level of the TyG index. The TyG index was determined as Ln (triglycerides [mg/dL] × fasting plasma glucose [mg/dL]/2).
Results:
Individuals with the highest TyG index showed an increased risk of MACEs compared to those with the lowest level of the TyG index (HR 1.60; 95% CI 1.11-2.30; P = 0.01). When analyzing the TyG index as a continuous variable, each standard deviation increase was associated with an HR of 1.51 (95% CI: 1.11-2.05; P = 0.01). For the male subgroup and the diabetes subgroup, this trend was even more pronounced (HR 1.269; 95% CI 1.055-1.527; P = 0.011; HR 1.385; 95% CI 1.125-1.706; P = 0.002). Additionally, the landmark analysis showed that patients with the highest level of TyG had an increased risk of MACEs 6 months after the PCI (P = 0.019).
Conclusion:
Elevated TyG index is associated with increased risk of adverse cardiovascular events in patients with ISR, and the extent of increase in the risk is more significant in male patients with diabetes.
