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Updated: Jun 18, 2025

05:37
Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
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A dual DNA-binding conjugate that selectively recognizes G-quadruplex structures
Mitsuharu Ooga1, Vinodh J Sahayasheela1, Yuki Hirose1
1Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. bando@kuchem.kyoto-u.ac.jp.
Abstract:
G-quadruplex (G4) structures play roles in various biological processes, but the challenge lies in specific targeting. To address this, we synthesized a conjugate capable of recognizing the G4 structure and its proximal duplex. Our conjugate can enable recognition of specific G4s in the human genome to understand and target those structures.

