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Naphthalimide-Based, Single-Chromophore, Emission Ratiometric Fluorescent Sensor for Tracking Intracellular pH
Sujit Kumar Das1, Smitaroopa Kahali1, Sabnam Kar2
1Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai, 400005, India.
Chembiochem : a European Journal of Chemical Biology
|July 29, 2024
Abstract:
We report a novel, reversible, cell-permeable, pH-sensor, TRapH. TRapH afforded a pH-sensitive ratiometric emission response in the pH range ~3-6, enabling imaging and quantification of pH in living cells. The biological-applicability of TRapH was illustrated via live-tracking of intracellular pH dynamics in living mammalian cells induced by a synthetic H+-transporter.

