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The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
Cord Blood Fetuin-B, Fetal Growth Factors, and Lipids in Gestational Diabetes Mellitus
Wen-Juan Wang1,2, Hua He1, Fang Fang1
1Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Early Life Health Institute, and Department of Pediatrics, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200092, China.
Context:
Fetuin-B is a hepatokine/adipokine implicated in glucose homeostasis and lipid metabolism.
Objective:
We sought to assess whether cord blood fetuin-B levels are altered in gestational diabetes mellitus (GDM) and the association with fetal growth factors and lipids.
Methods:
In a nested, case-control study of 153 pairs of neonates of mothers with GDM and euglycemic pregnancies in the Shanghai Birth Cohort, we assessed cord blood fetuin-B in relation to fetal growth factors and lipids (high-density lipoprotein, low-density lipoprotein [LDL], total cholesterol [TC], and triglycerides).
Results:
Cord blood fetuin-B concentrations were higher in the newborns of GDM vs euglycemic mothers (mean ± SD: 2.35 ± 0.96 vs 2.05 ± 0.73 mg/L; P = .012), and were positively correlated with LDL (r = 0.239; P < .0001), TC (r = 0.230; P = .0001), insulin-like growth factor-Ⅰ (IGF-Ⅰ) (r = 0.137; P = .023) and IGF-Ⅱ (r = 0.148; P = .014) concentrations. Similar associations were observed adjusting for maternal and neonatal characteristics.
Conclusion:
The study is the first to demonstrate that fetuin-B levels are elevated in fetal life in GDM, and that fetuin-B affects lipid metabolic health during fetal life in humans. The secretion of fetuin-B appears to be related to the secretion of IGF-Ⅰ and IGF-Ⅱ.
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