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Related Concept Videos

Methods for Studying Drug Absorption: In situ01:09

Methods for Studying Drug Absorption: In situ

221
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
221
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
191
Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

216
In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
216
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

125
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
125
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors01:19

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

168
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
168
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

247
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
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Updated: Jun 18, 2025

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Inulin: a multifaceted ingredient in pharmaceutical sciences.

Ruchi Tiwari1, Pranshul Sethi2, Shashi Ravi Suman Rudrangi3

  • 1Psit-Pranveer Singh Institute of Technology (Pharmacy), Kanpur, Uttar Pradesh, India.

Journal of Biomaterials Science. Polymer Edition
|July 29, 2024
PubMed
Summary
This summary is machine-generated.

Inulin, a plant-derived polysaccharide, offers significant pharmaceutical benefits as a prebiotic, improving gut health and metabolic processes. Its applications extend to drug delivery and managing conditions like diabetes and cardiovascular disease.

Keywords:
Inulincontrolled releasegut microbiotametabolic health

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Area of Science:

  • Pharmaceutical Sciences
  • Nutritional Science
  • Biochemistry

Background:

  • Inulin is a naturally occurring polysaccharide found in plants like chicory root.
  • It possesses diverse therapeutic and functional properties relevant to pharmaceutical applications.
  • Its role as a prebiotic and its impact on gut microbiota are key areas of interest.

Purpose of the Study:

  • To review the multifaceted applications of inulin in pharmaceutical sciences.
  • To explore its chemical structure, sources, mechanisms of action, and therapeutic potential.
  • To examine its use in drug formulation, delivery systems, and clinical efficacy.

Main Methods:

  • Literature review of scientific articles and clinical studies on inulin.
  • Analysis of inulin's chemical properties, biological activities, and pharmaceutical applications.
  • Evaluation of safety profiles and regulatory aspects.

Main Results:

  • Inulin acts as a prebiotic, modulating gut microbiota and enhancing gut health.
  • It shows therapeutic potential in managing diabetes, lipid metabolism, and gastrointestinal disorders.
  • Inulin serves as a stabilizing agent in drug formulations, improving bioavailability and enabling controlled release via systems like nanoparticles and hydrogels.

Conclusions:

  • Inulin demonstrates significant value in pharmaceutical sciences due to its prebiotic, therapeutic, and drug delivery enhancing properties.
  • Clinical studies support its efficacy in managing various health conditions.
  • Future research should focus on innovative applications and addressing associated challenges.