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Related Concept Videos

Structural Isomerism02:34

Structural Isomerism

Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can be...
Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...

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Related Experiment Video

Updated: Jul 22, 2026

A Technique to Functionalize and Self-assemble Macroscopic Nanoparticle-ligand Monolayer Films onto Template-free Substrates
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One-Pot Self-Assembly of Sequence-Controlled Mesoporous Heterostructures via Structure-Directing Agents.

Taylor Larison1, Eric R Williams1, Mason Wright1

  • 1Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.

ACS Nano
|July 29, 2024
PubMed
Summary

Researchers developed novel block polymers for self-assembling nanoscale porous heterostructures. This breakthrough allows precise control over material placement, mimicking nature

Keywords:
heterostructuremesoporousphosphonic acidself-assemblysequence control

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Area of Science:

  • Materials Science and Engineering
  • Nanotechnology
  • Polymer Chemistry

Background:

  • Multimaterial heterostructures exhibit properties superior to individual components.
  • Nature achieves complex heterostructures via biomineralization, but synthetic methods lack self-assembly elegance.
  • Current synthetic approaches for nanoscale heterostructures are limited and often fail to replicate natural self-assembly.

Purpose of the Study:

  • To develop block polymer structure-directing agents (SDAs) for fabricating nanoscale porous heterostructures.
  • To enable direct, self-assembled synthesis of heterostructures with controlled material localization.
  • To establish design rules for creating sequence-controlled, continuous porous heterostructures.

Main Methods:

  • Development of block polymer SDAs with repeat units for persistent (covalent) nanoparticle (NP) interactions.
  • Utilizing sequence-controlled polymer-NP interactions to direct heterostructure formation.
  • Investigating combinations of persistent and dynamic (noncovalent) SDA-NP interactions to optimize porosity and material localization.

Main Results:

  • Demonstrated fabrication of nanoscale porous heterostructures with single materials localized as continuous layers at pore surfaces.
  • Established design rule 1: Persistent SDA-NP binding enables sequence-controlled heterostructures based on synthetic order.
  • Showcased generalization with 5 material sequences (TiO2, Nb2O5, ZrO2) and introduced design rules 2 & 3 involving combined persistent/dynamic interactions for improved porosity.

Conclusions:

  • The developed block polymer SDAs facilitate direct self-assembly of advanced nanoscale porous heterostructures.
  • The three design rules enable precise control over material sequence, pore structure, and continuous porosity.
  • This approach offers a pathway to synthesize complex heterostructures with tailored properties, inspired by biomineralization.