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Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

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Primary spinal cord gliomas: Pathologic features associated with prognosis.

Yuki Tanaka^1,2, Manabu Natsumeda³, Masayuki Ohashi²

¹Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.

Journal of Neuropathology and Experimental Neurology

|July 29, 2024

Summary

Primary spinal cord gliomas have poorly defined features and high mortality. Immunohistochemistry markers like H3K27me3 loss and p53 positivity predict poor outcomes in these rare tumors.

Keywords:

EZHIP H3K27M H3K27me3 Ki-67 labeling index p53 primary spinal cord glioma

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Area of Science:

Neuropathology
Oncology
Molecular Diagnostics

Background:

Primary spinal cord gliomas are rare tumors with high mortality and poorly understood clinicopathological features.
Unlike brain tumors, specific diagnostic criteria and prognostic markers for spinal cord gliomas are not well-established.

Purpose of the Study:

To analyze the clinicopathological, histopathological, and immunohistochemical features of primary spinal cord gliomas.
To identify prognostic factors influencing overall survival (OS) in patients with spinal cord gliomas.

Main Methods:

Retrospective analysis of clinical data, histopathology, and immunohistochemistry (IHC) for IDH1 R132H, H3K27M, p53, and H3K27me3 in 25 patients.
Correlation of IHC findings and histopathological grades with overall survival (OS).

Main Results:

Gliomas were graded as WHO 1 (16%), 2 (20%), 3 (8%), and 4 (52%). One case had a rare molecular profile (H3K27-altered).
H3K27M positivity was found in 36% of patients, and H3K27me3 loss in 52%.
H3K27me3 loss, high p53 positivity (≥10%), high MIB-1 index (≥10%), and high histopathological grades significantly correlated with poor OS.

Conclusions:

Immunohistochemistry markers, including H3K27me3 loss and p53 expression, are crucial for assessing prognosis in primary spinal cord gliomas.
These pathological and immunohistochemical characteristics provide valuable insights into the prognosis of spinal cord gliomas.