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Updated: Jun 18, 2025

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
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Reciprocal interactions between lncRNAs and MYC in colorectal cancer: partners in crime

Zhen Lei1, Zhipu Zhu1, Zhihui Yao1

  • 1Translational Research Institute, People's Hospital of Zhengzhou University, Academy of Medical Science, Henan International Joint Laboratory of Non-coding RNA and Metabolism in Cancer, Tianjian Laboratory of Advanced Biomedical Sciences, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou, 450003, China.

Cell Death & Disease
|July 29, 2024
PubMed

Insights

This review explores the MYC and long noncoding RNA (lncRNA) axis in colorectal cancer (CRC). It details their reciprocal regulation and roles, highlighting potential therapeutic strategies for CRC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Proto-oncogenic MYC is frequently dysregulated in colorectal cancer (CRC).
  • Long noncoding RNAs (lncRNAs) are critical regulators in cancer development.
  • A complex interplay exists between MYC and lncRNAs in various cancers, including CRC.

Purpose of the Study:

  • To review the current understanding of the MYC and lncRNA axis in CRC.
  • To elucidate the mutual regulatory mechanisms between MYC and lncRNAs.
  • To explore the therapeutic potential of targeting this axis in CRC.

Main Methods:

  • Literature review of studies investigating MYC and lncRNA interactions in CRC.
  • Analysis of the roles of lncRNAs in regulating MYC expression and activity.
  • Examination of MYC's influence on lncRNA transcription and function.

Main Results:

  • MYC and lncRNAs exhibit reciprocal regulatory interactions in CRC.
  • lncRNAs modulate MYC expression at both transcriptional and post-transcriptional levels.
  • MYC influences lncRNA transcription, affecting cell fate decisions in CRC.

Conclusions:

  • The MYC-lncRNA axis plays a significant role in CRC pathogenesis.
  • Targeting the MYC-lncRNA interaction presents a promising therapeutic avenue for CRC.
  • Further research into this axis could lead to novel CRC treatment strategies.

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