Andrew C. G. Porter (1955-2023)

Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.

Transporters are essential membrane transport proteins with functions related to cell nutrition, homeostasis, communication, etc. Approximately 7% of all genes in the human genome code for transporters or transporter-related proteins.
Transporters are mainly composed of alpha-helices, built from bundles of ten or more helices traversing the plasma membrane. The solute-binding sites are located midway, where some of the helices are broken or distorted, making space for the binding site through...

In 1653, the French philosopher and scientist Blaise Pascal published "Treatise on the Equilibrium of Liquids," which discussed the principles of static fluids. A static fluid is a fluid that is not in motion. When a fluid is not flowing, we say that the fluid is in static equilibrium. If the fluid is water, we say it is in hydrostatic equilibrium. For a fluid in static equilibrium, the net force on any part of the fluid must be zero; otherwise, the fluid will start to flow. Pascal observed...

The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...

Carl Rogers, a key figure in humanistic psychology, believed that individuals possess an innate potential for growth and fulfillment. According to his model of personality, three significant components define an individual: the organism, the self, and conditions of worth.
The organism refers to an individual's inherent blueprint, which Rogers saw as innately positive and directed toward helping others, unlike Freud's view of the id as driven by base impulses. The self is a person's...

Gordon Allport, often regarded as the father of American personality psychology, developed a theory that emphasized the importance of understanding people in their present lives rather than focusing on their past, as psychoanalysis did. Allport believed that personality should be studied in healthy, well-adjusted individuals rather than those with psychological problems. He was particularly interested in defining traits, which he saw as fundamental mental structures that guide behavior across...