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Ketamine in fibromyalgia: a systematic review
Jozélio Freire de Carvalho1, Eduardo Pondé de Sena2
1Instituto de Ciencias da Saude da Universidade Federal da Bahia, Rua das Violetas, 42, ap. 502, Pituba, Salvador, Bahia, Brazil. jotafc@gmail.com.
Advances in Rheumatology (London, England)
|July 29, 2024
Summary
Ketamine shows short-term effectiveness and safety for fibromyalgia (FM) patients, offering an alternative to antidepressants. Further long-term studies are needed to confirm sustained benefits and safety in managing FM symptoms.
Area of Science:
- Anesthesiology
- Pain Management
- Rheumatology
Background:
- Fibromyalgia (FM) treatment often involves antidepressants with limited efficacy and potential adverse effects.
- Ketamine, an anesthetic, has emerged as a potential therapeutic agent for FM.
Purpose of the Study:
- To systematically review the safety and efficacy of ketamine in fibromyalgia patients.
Main Methods:
- A systematic literature search was conducted on PubMed for articles on FM and ketamine from 1966 to 2021.
- Study registration was performed at PROSPERO.
Main Results:
- Six articles involving 115 patients (predominantly female, ages 23-53) were analyzed.
- Ketamine administration varied (0.1-0.5 mg/kg IV or subcutaneous), showing significant short-term pain reduction (VAS 59-100 mm pre-treatment to 2-95 mm post-treatment).
- Common, transient side effects were observed during ketamine infusion.
Conclusions:
- Ketamine demonstrates short-term effectiveness and safety in managing fibromyalgia.
- More extensive research, including long-term follow-up studies, is required to fully establish ketamine's role in FM treatment.
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