Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Multitask Prediction Framework for CircRNAs, Drugs, and Diseases Based on Multi-View Information Integration and Graph Contrastive Learning.

ACS synthetic biology·2026

Same author

Protein N-glycosylation supports extravillous trophoblast cell lineage development in hypoxia microenvironment.

Life sciences·2026

Same author

Bibliometric Analysis of White Matter Disease and Novel Drug Therapy.

Current neuropharmacology·2026

Same author

Spinal neuromotor rehabilitation using a portable isokinetic training robot.

Nature·2026

Same author

An Interpretable PK-Informed Hybrid Model for Voriconazole Exposure Prediction: Roles of CYP2C19 Genotype and Inflammation.

Drug design, development and therapy·2026

Same author

Point-of-care testing reduces antibiotic prescribing for adults with community-acquired pneumonia: a systematic review and meta-analysis.

Frontiers in pharmacology·2026

Search research articles

Related Experiment Video

Updated: Jun 18, 2025

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice

Published on: April 10, 2019

Exosomes: the next-generation therapeutic platform for ischemic stroke.

Wenjing Yin¹, Hongyin Ma¹, Yang Qu¹

¹Stroke Center, Department of Neurology, First Hospital of Jilin University, Changchun, Jilin Province, China.

Neural Regeneration Research

|July 30, 2024

Summary

Exosomes show promise for treating ischemic stroke by reducing inflammation and promoting recovery. Further research is needed to standardize exosome isolation for effective clinical use.

More Related Videos

Formulating and Characterizing an Exosome-based Dopamine Carrier System

Formulating and Characterizing an Exosome-based Dopamine Carrier System

Published on: April 4, 2022

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

Related Experiment Videos

Last Updated: Jun 18, 2025

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice

Published on: April 10, 2019

Formulating and Characterizing an Exosome-based Dopamine Carrier System

Formulating and Characterizing an Exosome-based Dopamine Carrier System

Published on: April 4, 2022

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

Area of Science:

Neuroscience
Biotechnology
Regenerative Medicine

Background:

Current ischemic stroke treatments offer limited neurological recovery, necessitating novel therapeutic approaches.
Exosomes, natural cell-derived vesicles, possess beneficial properties like low immunogenicity, stability, and blood-brain barrier penetration, making them promising for stroke therapy.
Engineered exosomes, driven by nanotechnology, enhance targeting, efficacy, and reduce required dosages for ischemic stroke treatment.

Purpose of the Study:

To review the therapeutic effects of exosomes in ischemic stroke treatment.
To highlight the potential of exosomes in anti-inflammation, anti-apoptosis, angiogenesis, neurogenesis, and reducing glial scar formation.
To identify challenges and future directions for exosome-based therapies in ischemic stroke.

Main Methods:

Review of current literature on exosome biology and therapeutic applications in ischemic stroke.
Analysis of exosome properties relevant to neurological recovery.
Discussion of advancements in exosome engineering and clinical translation.

Main Results:

Exosomes demonstrate significant therapeutic potential through anti-inflammatory, anti-apoptotic, and pro-angiogenic effects.
Exosomes promote neurogenesis and reduce glial scar formation, contributing to functional recovery after ischemic stroke.
Engineered exosomes offer improved targeting and efficacy, with potential for reduced dosage requirements.

Conclusions:

Exosomes represent a promising therapeutic avenue for ischemic stroke, offering multifaceted benefits for neurological recovery.
Standardization of exosome isolation and characterization methods is crucial for clinical translation.
Further research and development of unified workflows are essential to harness the full potential of exosomes for ischemic stroke diagnosis and therapy.