Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Exercise and Cardiovascular Response

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Barium senses subtle pore changes in a voltage-gated K<sup>+</sup> channel associated with voltage sensor states and regulatory subunits.

Science advances·2026

Same author

A novel mouse model of combined blast and carbon monoxide-induced brain injury recapitulating coal mine gas explosions.

Experimental neurology·2026

Same author

Aerobic Exercise and Subthreshold Depressive Symptoms in Adolescents: Secondary Analysis of a Randomized Clinical Trial.

JAMA network open·2026

Same author

Regarding "Deteriorated Quality and Media Retraction of Tendon Following Acute Traumatic Rotator Cuff Tear Are Predictors of Retear After Arthroscopic Repair".

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2026

Same author

Time-resolved single-nucleus profiling of inter- and intracellular signaling in optic nerve injury: From the hyperacute phase to the acute phase.

Neural regeneration research·2026

Same author

Astrocytic FDX1 Contributes to Copper Dyshomeostasis-associated Synaptic Dysfunction in Depression and Is Modulated by Exercise.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Search research articles

Related Experiment Video

Updated: Jun 18, 2025

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin.

Meifeng Zheng^1,2,3, Borui Zhang³, Sonata S Y Yau⁴

¹Department of Rehabilitation Medicine, Guangzhou Medical University, Guangzhou, Guangdong Province, China.

Neural Regeneration Research

|July 30, 2024

Summary

Pre-exercise training before cerebral ischemia significantly reduces brain damage and improves memory. This protective effect is mediated by exercise-induced adiponectin, a key circulating factor.

More Related Videos

Use of a Hanging Weight System for Coronary Artery Occlusion in Mice

Use of a Hanging Weight System for Coronary Artery Occlusion in Mice

Published on: April 19, 2011

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Related Experiment Videos

Last Updated: Jun 18, 2025

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

Use of a Hanging Weight System for Coronary Artery Occlusion in Mice

Use of a Hanging Weight System for Coronary Artery Occlusion in Mice

Published on: April 19, 2011

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Area of Science:

Neuroscience
Exercise Physiology
Metabolic Research

Background:

Cerebral ischemia poses a significant health risk, necessitating preventive strategies beyond drug therapy.
Physical exercise is known to promote neurogenesis and synaptogenesis, aiding post-stroke rehabilitation.
The potential of pre-emptive exercise training to mitigate cerebral ischemia severity remains an area of investigation.

Purpose of the Study:

To investigate the efficacy of exercise pre-conditioning in attenuating cerebral ischemia.
To elucidate the role of exercise-induced circulating factors in this protective effect.
To determine the specific involvement of adiponectin in exercise-mediated neuroprotection.

Main Methods:

Adult mice underwent 14 days of treadmill exercise training prior to middle cerebral artery occlusion surgery.
Assessment of brain infarct area, gliogenesis, and synaptic protein levels.
Evaluation of cognitive function using novel object and spatial memory tests.
Pharmacological manipulation of adiponectin receptor activation using AdipoRon.

Main Results:

Exercise pre-conditioning significantly reduced brain infarct size and gliogenesis.
Synaptic protein protection and improved performance in memory tasks were observed.
Circulating adiponectin was identified as a critical mediator of these benefits.
AdipoRon mimicked exercise effects, while receptor inhibition abolished them.

Conclusions:

Exercise pre-conditioning offers a protective strategy against cerebral ischemia.
Circulating adiponectin plays a pivotal role in mediating the neuroprotective effects of exercise.
These findings highlight adiponectin as a potential therapeutic target for stroke prevention.