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The Interplay between Cardiovascular Disease, Exercise, and the Gut Microbiome

Candace R Longoria1, John J Guers2, Sara C Campbell1

  • 1Department of Kinesiology and Health, Rutgers University, New Brunswick, NJ 08901, USA.

Reviews in Cardiovascular Medicine
|July 30, 2024
PubMed

Insights

Physical inactivity contributes to cardiovascular disease (CVD). Research suggests exercise and gut microbiota manipulation may offer new avenues for CVD prevention and treatment.

Area of Science:

  • Microbiology
  • Cardiology
  • Exercise Science

Background:

  • Cardiovascular disease (CVD) is a leading global cause of mortality.
  • Physical inactivity is a significant risk factor for CVD.
  • The gut microbiota is increasingly recognized for its role in various diseases, including CVD, type 2 diabetes, and obesity.

Purpose of the Study:

  • To review current research on the relationship between gut microbiota, exercise, and cardiovascular disease risk.
  • To explore the potential of manipulating the gut microbiota and/or exercise for CVD treatment.

Main Methods:

  • This review synthesizes findings from existing research studies.
  • It examines the impact of diet, exercise, and lifestyle on the gut microbiome and CVD outcomes.
  • The review discusses the detection of gut dysbiosis as an early indicator of disease states.

Main Results:

  • Whole-food diets are linked to reduced CVD incidence, increased beneficial gut bacteria, and altered metabolite production.
  • Exercise and increased physical activity improve CVD risk factors and enhance gut microbial diversity.
  • Gut microbiota dysbiosis is associated with CVD and its comorbidities.

Conclusions:

  • Exercise, lifestyle modifications, and gut microbiota composition individually contribute to improved cardiovascular health.
  • Further research into the interplay between the gut microbiome, exercise, and CVD may lead to novel therapeutic strategies.
  • Targeting the gut microbiota and promoting physical activity show promise for CVD prevention and management.

Keywords:
endothelial functiongut microbiotainflammationmetabolitesprebioticsprobioticstrimethylamine N-oxide (TMAO)

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