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Drug-coated Balloons in the Neurovascular Setting: A Comprehensive, Systematic Review of Current Use and Indications
Philipp von Gottberg1, Alexandru Cimpoca1, Christina Wendl2
1Neuroradiologische Klinik, Klinikum Stuttgart, 70174 Stuttgart, Germany.
Insights
Drug-coated balloons (DCB) show potential benefits for treating neurovascular restenosis. However, more research is needed as current data on DCB use in cervical and intracranial arteries is limited.
Area of Science:
- Interventional Neurology
- Vascular Medicine
- Medical Device Technology
Background:
- Drug-coated balloons (DCB) are widely used for coronary and peripheral artery restenosis.
- Restenosis mechanisms in neurovascular arteries are similar to peripheral and coronary arteries.
- Limited data exists on DCB application in cervical and intracranial arteries.
Purpose of the Study:
- To review existing data on the use of DCB in neurovascular arteries.
- To assess the potential benefits of DCB compared to other treatment modalities.
Main Methods:
- Systematic search of Medline database.
- Inclusion of international and national guidelines and recommendations.
- Review of 166 publications out of 1448 relevant records.
Main Results:
- Identified a potential benefit of DCB over alternative treatments like self-expanding stents and drug-eluting stents.
- Highlighted the scarcity of research and publications regarding DCB in the neurovascular field.
Conclusions:
- DCB may offer advantages in treating neurovascular restenosis.
- Further research is critically needed to establish the role and efficacy of DCB in neurovascular applications.
Background:
Drug-coated balloons (DCB) are an established tool in the prevention and treatment of coronary and peripheral artery restenosis. The underlying effects of restenosis resemble those in the neurovascular field, yet data on the use of DCB in cervical and intracranial arteries is rare.
Methods:
Medline, and international and major national guidelines and recommendations were systematically searched for data addressing the use of DCB in the neurovascular setting.
Results:
Of the 1448 relevant records found in Medline, 166 publications were considered for this review.
Conclusions:
Data on the use of DCB in the neurovascular setting show a possible benefit over preceding alternatives, such as self-expanding stents, and balloon-mounted or drug-eluting stents. Nonetheless, the role of DCB remains under-researched, and publications remain lacking.
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