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Related Experiment Video

Updated: May 5, 2026

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
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Intravenous Tranexamic Acid Reduces Post-Operative Bleeding and Blood Transfusion in Patients Undergoing Aortic

Bo Zhang1, Li-Xian He2, Yun-Tai Yao3

  • 1Department of Anesthesiology, Tianjin Union Medical Center, 300121 Tianjin, China.

Reviews in Cardiovascular Medicine
|July 30, 2024
PubMed
Summary

Tranexamic acid (TXA) significantly reduces bleeding and transfusion needs in aortic surgery. This antifibrinolytic agent also lowers the risk of postoperative complications, improving patient outcomes.

Keywords:
aortic surgerypost-operative bleedingtranexamic acid

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Area of Science:

  • Cardiovascular Surgery
  • Anesthesiology
  • Pharmacology

Background:

  • Tranexamic acid (TXA) is an established antifibrinolytic agent used to reduce blood loss in various surgical procedures.
  • Evidence for its efficacy in aortic surgery remains limited, necessitating further investigation.

Purpose of the Study:

  • To evaluate the effectiveness of intravenous tranexamic acid (TXA) in reducing blood loss and transfusion requirements in patients undergoing aortic surgery.
  • To assess the impact of TXA on postoperative complications in this patient population.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases (PubMed, EMBASE, OVID, Cochrane Library, CNKI) for relevant randomized controlled trials (RCTs).
  • Data from 4 RCTs involving 273 patients were extracted and analyzed using meta-analysis techniques.
  • Risk of bias was evaluated, and random or fixed effect models were employed for data pooling.

Main Results:

  • Intravenous TXA significantly reduced postoperative bleeding within the first 4 and 24 hours.
  • TXA administration led to decreased requirements for red blood cell (RBC), fresh frozen plasma (FFP), and platelet concentrate (PC) transfusions.
  • A significant reduction in the incidence of postoperative complications was observed with TXA use (OR = 0.47, p = 0.001).

Conclusions:

  • Tranexamic acid (TXA) demonstrates significant efficacy in minimizing postoperative bleeding and blood transfusion needs in aortic surgery.
  • TXA also appears to reduce the occurrence of postoperative complications, suggesting a favorable safety and efficacy profile.
  • Further high-quality studies are recommended to definitively confirm the benefits of intravenous TXA in aortic surgery patients.