Comparison of Cardiac Activated Fibroblast Imaging and Magnetic Resonance Imaging in Patients with COVID-19-Related Myocarditis
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View abstract on PubMed
Summary
This summary is machine-generated.Cardiac fibroblast activation, assessed by 99mTc-HFAPi imaging, is elevated in COVID-19 myocarditis. This activation correlates with native T1 values from cardiac magnetic resonance (CMR) imaging.
Area Of Science
- Cardiology
- Radiology
- Infectious Diseases
Background
- Myocarditis following COVID-19 infection can lead to cardiac complications.
- Cardiac fibroblast activation is a key process in myocardial remodeling and fibrosis.
Purpose Of The Study
- To investigate the association between cardiac fibroblast activation and cardiac magnetic resonance (CMR) imaging parameters in patients with COVID-19-related myocarditis.
- To evaluate the utility of 99mTc-HFAPi SPECT/CT in assessing fibroblast activation in this patient group.
Main Methods
- A prospective study involving four patients with COVID-19-related myocarditis.
- Utilized both 99mTc-HFAPi SPECT/CT and CMR imaging.
- Quantified segmental 99mTc-HFAPi activity and analyzed CMR parameters including T1/T2 values, extracellular volume (ECV), and late gadolinium enhancement (LGE).
Main Results
- A higher proportion of segments showed abnormal 99mTc-HFAPi activity compared to abnormal LGE, T2, and ECV.
- The proportion of abnormal 99mTc-HFAPi activity was similar to abnormal native T1 values.
- 99mTc-HFAPi imaging demonstrated good consistency with native T1 values (kappa = 0.69).
Conclusions
- Elevated cardiac 99mTc-HFAPi activity is indicative of fibroblast activation in COVID-19-related myocarditis.
- Cardiac fibroblast activation, as measured by 99mTc-HFAPi, shows a correlation with native T1 values obtained through CMR.
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