Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Bone Remodeling01:40

Bone Remodeling

38.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.2K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

3.8K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
3.8K
What is the Skeletal System?01:02

What is the Skeletal System?

52.3K
Overview
52.3K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ADNP Functions During Early Brain Development and Their Relevance to ASD and ADNP Syndrome.

International journal of molecular sciences·2026
Same author

Spectral CT in radiotherapy: physics, principles, clinical applications, and future outlooks.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same author

Increased precipitation decelerates temporal succession of grassland soil microbial communities.

The ISME journal·2026
Same author

[Construction and application of early warning and grading intervention strategy for critically ill inpatients based on dynamic sequential organ failure assessment scoring].

Zhonghua wei zhong bing ji jiu yi xue·2026
Same author

PEDF peptides rescue defects in neurite morphogenesis and intracellular calcium response in cortical neurons from mice exposed to valproic acid.

bioRxiv : the preprint server for biology·2026
Same author

Drug repurposing of sophoridine for sepsis-induced organ injury: from in-depth analysis of a single agent to a multi-target therapeutic paradigm.

Frontiers in pharmacology·2026

Related Experiment Video

Updated: Jun 18, 2025

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

2.3K

Microbiota-bone axis in ageing-related bone diseases.

Liangxuan Fu1, Peilin Zhang1, Yicheng Wang1

  • 1Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in Endocrinology
|July 30, 2024
PubMed
Summary

The gut microbiota significantly influences bone metabolism and aging. Targeting gut bacteria offers a novel therapeutic strategy for age-related bone diseases like osteoporosis.

Keywords:
agingbonebone metabolismgut microbiotaskeletal degenerative diseases

More Related Videos

Studying Orthodontic Tooth Movement in Mice
07:17

Studying Orthodontic Tooth Movement in Mice

Published on: August 2, 2024

669
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.6K

Related Experiment Videos

Last Updated: Jun 18, 2025

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

2.3K
Studying Orthodontic Tooth Movement in Mice
07:17

Studying Orthodontic Tooth Movement in Mice

Published on: August 2, 2024

669
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.6K

Area of Science:

  • Microbiology
  • Bone Biology
  • Gerontology

Background:

  • Bone homeostasis relies on balanced bone formation and resorption.
  • Aging disrupts bone homeostasis, increasing susceptibility to bone diseases.
  • Gut microbiota plays a critical role in regulating host health and metabolism.

Purpose of the Study:

  • To review the complex interplay between gut microbiota and bone metabolism.
  • To explore the role of gut microbiota in bone aging and related diseases.
  • To identify gut microbiota as a therapeutic target for bone aging.

Main Methods:

  • Literature review of studies on gut microbiota and bone metabolism.
  • Analysis of host-microbiota crosstalk mechanisms.
  • Examination of gut microbiota's impact on aging-related bone conditions.

Main Results:

  • Gut microbiota significantly impacts bone metabolism through endocrine, immune, and metabolic pathways.
  • Alterations in gut microbiota are implicated in osteoporosis, fracture repair, osteoarthritis, and spinal degeneration.
  • Gut microbiota metabolites influence bone health during aging.

Conclusions:

  • Gut microbiota is a key factor in the pathogenesis of aging-related bone diseases.
  • Understanding host-microbiota interactions is crucial for grasping bone aging.
  • Targeting the gut microbiota presents a promising clinical strategy for treating bone aging diseases.